Idiopathic focal segmental glomerulosclerosis and HLA antigens

Idiopathic focal segmental glomerulosclerosis and HLA antigens

Autor Gerbase-Lima, Maria Autor UNIFESP Google Scholar
Pereira-Santos, A. Autor UNIFESP Google Scholar
Sesso, Ricardo de Castro Cintra Autor UNIFESP Google Scholar
Temin, Julia Google Scholar
Aragão, E.s. Google Scholar
Ajzen, Horacio Autor UNIFESP Google Scholar
Instituição A01
Universidade Federal de São Paulo (UNIFESP)
Resumo The objective of the present study was to investigate a possible association between HLA class II antigens and idiopathic focal segmental glomerulosclerosis (FSGS). HLA-A, -B, -DR and -DQ antigens were determined in 19 Brazilian patients (16 white subjects and three subjects of Japanese origin) with biopsy-proven FSGS. Comparison of the HLA antigen frequencies between white patients and white local controls showed a significant increase in HLA-DR4 frequency among FSGS patients (37.7 vs 17.2%, P<0.05). In addition, the three patients of Japanese extraction, not included in the statistical analysis, also presented HLA-DR4. In conclusion, our data confirm the association of FSGS with HLA-DR4 previously reported by others, thus providing further evidence for a role of genes of the HLA complex in the susceptibility to this disease
Palavra-chave focal segmental glomerulosclerosis
genetics
HLA antigens
MHC
Idioma Inglês
Data de publicação 1998-03-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 3, p. 387-389, 1998.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 387-389
Fonte http://dx.doi.org/10.1590/S0100-879X1998000300010
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000073337200010
SciELO S0100-879X1998000300010 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/590

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