Response to immunization in children born to renal transplant recipients using immunosuppressive drugs during gestation

Response to immunization in children born to renal transplant recipients using immunosuppressive drugs during gestation

Author Dinelli, Maria Isabel Saraiva Autor UNIFESP Google Scholar
Ono, Erika Autor UNIFESP Google Scholar
Viana, Patricia Oliveira Autor UNIFESP Google Scholar
Spina, Fernanda Garcia Autor UNIFESP Google Scholar
Weckx, Lily Yin Autor UNIFESP Google Scholar
Nunes dos Santos, Amelia Miyashiro Autor UNIFESP Google Scholar
de Moraes-Pinto, Maria Isabel Autor UNIFESP Google Scholar
Abstract The use of immunosuppressive drugs can impair vaccination responses. When used during pregnancy, they may interfere with the development of the fetus's immune system. However, little is known regarding their influence on infant's response to vaccinations. Twenty-seven children born to renal transplant mothers (Tx) taking immunosuppressive drugs and 31 healthy children had the humoral immune response and reactogenicity to tetanus, Haemophilus influenzae type b (Hib) and 7 pneumococcal serotypes evaluated. The evolution of BCG vaccine scar was also registered. Antibodies were measured by ELISA. Lymphocyte immunophenotyping was performed on cord blood and at 7-8 months of age. Among Tx neonates, 82.4% had low B lymphocyte numbers at birth, and 29.4% had also low numbers of other lymphocyte subpopulations. Nevertheless, all children developed protective antibodies with similar antibody concentrations to the control group. Vaccine reactogenicity was similar in both groups and BCG healing was uneventful. (C) 2015 Elsevier Ltd. All rights reserved.
Keywords Immunosuppression
Gestation
Solid organ transplantation
Vaccine
Immunization
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor FAPESP, Brazil
CAPES, Brazil
Grant number FAPESP: 2008/11670-9
Date 2016
Published in Vaccine. Oxford, v. 34, n. 4, p. 404-407, 2016.
ISSN 0264-410X (Sherpa/Romeo, impact factor)
Publisher Elsevier Sci Ltd
Extent 404-407
Origin https://doi.org/10.1016/j.vaccine.2015.12.017
Access rights Closed access
Type Article
Web of Science ID WOS:000368868100003
URI https://repositorio.unifesp.br/handle/11600/58545

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