Factors associated with the time to the first wheezing episode in infants: a cross-sectional study from the International Study of Wheezing in Infants (EISL)

Factors associated with the time to the first wheezing episode in infants: a cross-sectional study from the International Study of Wheezing in Infants (EISL)

Author Pacheco-Gonzalez, Rosa M. Google Scholar
Mallol, Javier Google Scholar
Sole, Dirceu Autor UNIFESP Google Scholar
Brand, Paul L. P. Google Scholar
Perez-Fernandez, Virginia Google Scholar
Sanchez-Solis, Manuel Google Scholar
Garcia-Marcos, Luis Google Scholar
Abstract Male gender, asthmatic heredity, perinatal tobacco smoke exposure and respiratory infections have been associated with wheeze in the first years of life, among other risk factors. However, information about what factors modify the time to the first episode of wheeze in infants is lacking. The present study analyses which factors are associated with shorter time to the first episode of wheeze in infants. Parents of 11- to 24-month-old children were surveyed when attending their health-care centres for a control visit. They answered a questionnaire including the age in months when a first wheeze episode (if any) had occurred (outcome variable). The study was performed in 14 centres in Latin America (LA) and in 8 centres in Europe (EU) (at least 1,000 infants per centre). Factors known to be associated with wheezing in the cohort were included in a survival analysis (Cox proportional hazards model). Summary hazard ratios adjusted for all risk factors (aHR) were calculated using the meta-analysis approach with random effects. A total of 15,067 infants had experienced wheezing at least once, out of 35,049 surveyed. Male gender in LA (aHR 1.05, 95% confidence interval (CI) 1.00-1.10, P = 0.047), parental asthma in LA and EU (aHR 1.05, 95% CI 1.00-1.11, P = 0.037), infant eczema in EU (aHR 1.25, 95% CI 1.12-1.39, P < 0.001) and having a cold during the first 3 months in LA and EU (aHR 1.97, 95% CI 1.90-2.04, P < 0.001), in LA (aHR 1.98, 95% CI 1.90-2.06, P < 0.001) and in EU (aHR 1.91, 95% CI 1.75-2.09, P < 0.001) were associated with a shorter period of time to the first episode. Breast feeding for at least 3 months was associated with a longer period, only in LA (aHR 0.91, 95% CI 0.86-0.96, P < 0.001). Cold symptoms during the first 3 months is the most consistent factor shortening the time to the first episode of wheezing; breast feeding for >= 3 months delays it only in LA, whereas eczema shortens it only in EU. Avoiding a common cold in the first months of life could be a good strategy to delay the first wheeze episode; however, cohort studies will help to elucidate this association.
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Spanish 'Fondo de Investigacion Sanitaria'
'Secretaria de Estado para la Cooperacion Internacional'
Regional Government of Murcia, Spain
Foundation to Combat Asthma (Stichting Astmabestrijding), Amsterdam, The Netherlands
Grant number Spanish 'Fondo de Investigacion Sanitaria': PI050480
'Secretaria de Estado para la Cooperacion Internacional': A/3069/05
'Secretaria de Estado para la Cooperacion Internacional': A/5189/06
Date 2016
Published in Npj Primary Care Respiratory Medicine. New York, v. 26, p. -, 2016.
ISSN 2055-1010 (Sherpa/Romeo, impact factor)
Publisher Nature Publishing Group
Extent -
Origin https://doi.org/10.1038/npjpcrm.2015.77
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000368548000001
URI https://repositorio.unifesp.br/handle/11600/58544

Show full item record




File

Name: WOS000368548000001.pdf
Size: 409.1Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account