Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample

Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample

Author Cunha, G. R. Autor UNIFESP Google Scholar
Asevedo, E. Autor UNIFESP Google Scholar
Mansur, R. B. Autor UNIFESP Google Scholar
Zugman, A. Autor UNIFESP Google Scholar
Pan, P. M. Autor UNIFESP Google Scholar
Gadelha, A. Autor UNIFESP Google Scholar
Belangero, S. I. Autor UNIFESP Google Scholar
Rizzo, L. B. Autor UNIFESP Google Scholar
Coelho, R. Google Scholar
Stertz, L. Google Scholar
Cogo-Moreira, H. Autor UNIFESP Google Scholar
Grassi-Oliveira, R. Google Scholar
Teixeira, A. L. Google Scholar
Kauer-Sant'Anna, M. Google Scholar
Mari, J. J. Autor UNIFESP Google Scholar
Miguel, E. C. Google Scholar
Bressan, R. A. Autor UNIFESP Google Scholar
Brietzke, E. Autor UNIFESP Google Scholar
Abstract Objective: To investigate the association between peripheral biomarkers and child psychopathology in a large community sample. Method: A total of 625 aged 6- to 13-year old subjects were recruited from a community school-based study. Psychopathology was assessed using the Child Behaviour Checklist (CBCL). Psychiatric diagnosis was evaluated using the Development and Well-Being Assessment. The following biomarkers were examined in peripheral blood: brain-derived neurotrophic factor, cytokines (IL-2, IL-4, IL-6, IL-10, IL-17, IFN-g, and TNF-alpha), chemokines (eotaxin/CCL11, IP-10, MCP-1), cytokine receptors (sTNFR1 and sTNFR2), and the oxidative stress marker TBARS. Results: We found significant associations between sTNFR2, eotaxin/CCL11 and CBCL total score, as well as with specific dimensions of psychopathology. There were different patterns of association between these biomarkers and psychological and behavioural symptoms in children with and without a mental disorder. TBARS, IL-6 and MCP-1 were more specific to some clusters of symptoms in children with a psychiatric diagnosis. Conclusion: Our data support the potential use of biomarkers, especially those involved in immune-inflammatory pathways, in investigating neurodevelopmental psychopathology. Their association with different dimensions of symptoms might be of useful when analyzing illness severity and clusters of symptoms within specific disorders.
Keywords mental disorders
biomarkers
childhood
adolescence
psychopathology
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor National Institute of Developmental Psychiatry for Children and Adolescents, a science and technology institute - Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP; Research Support Foundation of the State of Sao Paulo)
Grant number CNPq: 573974/2008-0
FAPESP: 2008/57896-8
Date 2016
Published in Acta Psychiatrica Scandinavica. Hoboken, v. 133, n. 2, p. 122-132, 2016.
ISSN 0001-690X (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent 122-132
Origin https://doi.org/10.1111/acps.12453
Access rights Closed access
Type Article
Web of Science ID WOS:000368003600004
URI https://repositorio.unifesp.br/handle/11600/58517

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