Treatment of patients with uric acid stones

Treatment of patients with uric acid stones

Author Heilberg, Ita Pfeferman Autor UNIFESP Google Scholar
Abstract Uric acid nephrolithiasis and unduly acidic urinary pH are both considered a renal manifestation of insulin resistance but the underlying mechanisms for the development of low urinary pH and the propensity for uric acid stone formation are not completely elucidated. Nevertheless, excessive dietary acid intake, increased endogenous acid production and/or defective NH4+ excretion play an important role, among other factors. The main principles of therapy for uric acid nephrolithiasis are aimed at urinary alkalinization through diet modification or pharmacologic agents, increase of urinary volume, and less importantly at the reduction of uric acid excretion.
Keywords Uric acid
Stones
Nephrolithiasis
Urate
Acidic pH
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Conselho Nacional de Pesquisa e Desenvolvimento (CNPq)
Grant number CNPq: 305638/2012-2
Date 2016
Published in Urolithiasis. New York, v. 44, n. 1, p. 57-63, 2016.
ISSN 2194-7228 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 57-63
Origin https://doi.org/10.1007/s00240-015-0843-8
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000368811600008
URI https://repositorio.unifesp.br/handle/11600/58516

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