Ocimum gratissimum Essential Oil and Its Isolated Compounds (Eugenol and Myrcene) Reduce Neuropathic Pain in Mice

Ocimum gratissimum Essential Oil and Its Isolated Compounds (Eugenol and Myrcene) Reduce Neuropathic Pain in Mice

Author Paula-Freire, Lyvia Izaura Gomes Autor UNIFESP Google Scholar
Molska, Graziella Rigueira Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Carlini, Elisaldo Araujo Autor UNIFESP Google Scholar
Abstract Ocimum gratissimum is used in popular medicine to treat painful diseases. The antihypernociceptive properties of O. gratissimum essential oil and two of its active components (eugenol and myrcene) were tested in a model of neuropathic pain induced by a chronic constriction injury of the sciatic nerve. In tests to determine chronic antinociception, adult male C57BL/6 J mice were treated orally with corn oil (control group), O. gratissimum essential oil at doses of 10, 20, or 40 mg/kg or eugenol or myrcene at doses of 1, 5, or 10 mg/kg for 14 days after surgery. Pregabalin (20mg/ kg) was used as a standard in this study. The treatment with 20 and 40mg/kg of O. gratissimum essential oil and at doses of 5 and 10 mg/kg of the active components were able to promote antihypernociception in both mechanical (von Frey) and thermal (hot plate) tests. The treatment with the essential oil of the plant or eugenol was effective in reducing the levels of interleukin-1 beta in the sciatic nerve. Our findings demonstrate that O. gratissimum essential oil and its isolated active components possess antihypernociceptive activity in neuropathic pain models.
Keywords Ocimum gratissimum
Lamiaceae
eugenol
myrcene
neuropathic pain
IL-1beta
xmlui.dri2xhtml.METS-1.0.item-coverage Stuttgart
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Centro Brasileiro de Informacoes sobre Drogas Psicotropicas (CEBRID)
Associacao Fundo de Incentivo a Pesquisa (AFIP)
Grant number FAPESP: 09/51881-1
Date 2016
Published in Planta Medica. Stuttgart, v. 82, n. 3, p. 211-216, 2016.
ISSN 0032-0943 (Sherpa/Romeo, impact factor)
Publisher Georg Thieme Verlag Kg
Extent 211-216
Origin https://doi.org/10.1055/s-0035-1558165
Access rights Closed access
Type Article
Web of Science ID WOS:000369948100005
URI https://repositorio.unifesp.br/handle/11600/58480

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