Sleep-related movement disorder symptoms in SHR are attenuated by physical exercise and an angiotensin-converting enzyme inhibitor

Sleep-related movement disorder symptoms in SHR are attenuated by physical exercise and an angiotensin-converting enzyme inhibitor

Author Frank, Miriam Kannebley Google Scholar
Mello, Marco Tulio de Google Scholar
Lee, Kil Sun Autor UNIFESP Google Scholar
Daubian-Nose, Paulo Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Esteves, Andrea Maculano Google Scholar
Abstract The relationship between hypertension and sleep-related movement disorders has been hypothesized for humans, but the causes and mechanisms have not been elucidated. We investigated whether an alteration in blood pressure (BP) induced by physical exercise and/or an angiotensin-converting enzyme inhibitor (enalapril) could affect locomotor activity in spontaneously hypertensive rats, with emphasis on the dopaminergic system. We used SHR and normotensive Wistar rats distributed into 4 groups for each strain: control, physical exercise, enalapril and physical exercise + enalapril. Physical exercise was performed on a treadmill, and enalapril was administered by gavage, both for 8 weeks. During this period, locomotor activity was evaluated in an open field test, and BP was evaluated by tail plethysmography. Dopaminergic receptors, dopamine transporter and tyrosine hydroxylase levels at the striatum were evaluated by Western blotting. The control group of spontaneously hypertensive rats showed higher BP, increased activity in the open field test and lower levels of D2 receptors and tyrosine hydroxylase compared with all other groups throughout the experimental period. In general, physical exercise and enalapril attenuated these alterations. This study suggested the existence of comorbidity between hypertension and sleep-related movement disorders in spontaneously hypertensive rats. Physical exercise and enalapril conferred protection for both hypertension and the observed behavioral changes. In addition, these treatments led to changes in dopaminergic signaling in the striatal region (i.e., D2 receptor, TH and DAT). (C) 2015 Elsevier Inc All rights reserved.
Keywords Spontaneously hypertensive rats
Restless legs syndrome
Physical exercise
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Associação Fundo de Incentivo a Pesquisa
Grant number FAPESP: 2011/21729-3
FAPESP: 2013/22413-5
Date 2016
Published in Physiology & Behavior. Oxford, v. 154, p. 161-168, 2016.
ISSN 0031-9384 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 161-168
Access rights Closed access
Type Article
Web of Science ID WOS:000369207000021

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