Methadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of Catecholamines

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dc.contributor.author Pignaton, Wangles
dc.contributor.author Luna, Stelio Pacca Loureiro
dc.contributor.author Teixeira Neto, Francisco Jose
dc.contributor.author de Oliveira, Flavia Augusta
dc.contributor.author de Castro Neto, Eduardo Ferreira [UNIFESP]
dc.contributor.author Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
dc.contributor.author Gozalo-Marcilla, Miguel
dc.date.accessioned 2020-10-30T18:46:27Z
dc.date.available 2020-10-30T18:46:27Z
dc.date.issued 2016
dc.identifier https://doi.org/10.1016/j.jevs.2015.10.014
dc.identifier.citation Journal Of Equine Veterinary Science. New York, v. 37, p. 39-45, 2016.
dc.identifier.issn 0737-0806
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/58468
dc.description.abstract Catecholamines and arginine vasopressin (AVP) release can affect arterial blood pressure (ABP) and hemodynamic stability in standing, sedated horses. Six mature horses were included in this prospective, randomized, crossover, blinded, experimental study. All the horses were sedated with detomidine (DET) alone (0.01 mg/kg, IV) or combined with methadone (MET) (0.01 mg/kg DET and 0.2 mg/kg MET, IV). Cardiopulmonary data and blood samples were collected 30 minutes before (prebaseline and baseline) and for 120 minutes postinjection. The combination DET/MET produced a significant increase (31%) in mean ABP (MAP) 5 minutes after drug administration which lasted for 120 minutes. Detomidine alone induced only a short-term increase in MAP (15%) at 5 minutes compared with baseline. There were significant differences between groups at 5, 15, and from 60 to 120 minutes. Plasma AVP concentrations were higher in horses receiving the treatment DET from 60 to 120 minutes than those in the combination group, for the same period. There were no significant differences in norepinephrine and epinephrine serum concentrations respect to baseline and between treatments. Detomidine induces a short-term MAP increase, and this effect was prolonged and potentiated by MET association. There is no evidence of AVP, norepinephrine, and epinephrine involvement in this effect. (C) 2016 Elsevier Inc. All rights reserved. en
dc.description.sponsorship Sao Paulo Research Foundation (FAPESP)
dc.format.extent 39-45
dc.language.iso eng
dc.publisher Elsevier Science Inc
dc.relation.ispartof Journal Of Equine Veterinary Science
dc.rights Acesso restrito
dc.subject Cardiovascular system en
dc.subject Adrenergic alpha-2 agonist en
dc.subject Analgesic en
dc.subject Opioid en
dc.subject Equine en
dc.subject Arterial blood pressure en
dc.title Methadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of Catecholamines en
dc.type Artigo
dc.description.affiliation UNESP Univ Estadual Paulista, Sch Med, Dept Anesthesiol, Sao Paulo, Brazil
dc.description.affiliation UNESP Univ Estadual Paulista, Sch Vet Med & Anim Sci, Dept Vet Surg & Anesthesiol, Dist Rubiao Jr S-N, BR-18618970 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Biochem, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Biochem, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2008/56362-0
dc.identifier.doi 10.1016/j.jevs.2015.10.014
dc.description.source Web of Science
dc.identifier.wos WOS:000370377900006
dc.coverage New York
dc.citation.volume 37



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