Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients

Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients

Autor Morais, Clarice Neuenschwander Lins de Google Scholar
Carvalho, Bruno de Melo Google Scholar
Melo, Wlademir Gomes de Google Scholar
Melo, Fábio Lopes de Google Scholar
Lopes, Edmundo Pessoa de Almeida Google Scholar
Domingues, Ana Lúcia Coutinho Google Scholar
Jucá, Norma Google Scholar
Martins, João Roberto Maciel Autor UNIFESP Google Scholar
Diniz, George Tadeu Nunes Google Scholar
Montenegro, Silvia Maria Lucena Google Scholar
Instituição Fiocruz Centro de Pesquisas Aggeu Magalhães Departamento de Imunologia
Universidade Federal de Pernambuco
Universidade Federal de São Paulo (UNIFESP)
Resumo Liver biopsy is the gold-standard method to stage fibrosis; however, it is an invasive procedure and is potentially dangerous. The main objective of this study was to evaluate biological markers, such as cytokines IL-13, IFN-γ, TNF-α and TGF-β, platelets, bilirubins (Bil), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), total proteins, γ-glutamil transferase (γ-GT) and alkaline phosphatase (AP), that could be used to predict the severity of hepatic fibrosis in schistosomiasis and hepatitis C (HC) as isolated diseases or co-infections. The following patient groups were selected: HC (n = 39), HC/hepatosplenic schistosomiasis (HSS) (n = 19), HSS (n = 22) and a control group (n = 13). ANOVA and ROC curves were used for statistical analysis. P < 0.05 was considered significant. With HC patients we showed that TNF-α (p = 0.020) and AP (p = 0.005) could differentiate mild and severe fibrosis. With regard to necroinflammatory activity, AST (p = 0.002), γ-GT (p = 0.034) and AP (p = 0.001) were the best markers to differentiate mild and severe activity. In HC + HSS patients, total Bil (p = 0.008) was capable of differentiating between mild and severe fibrosis. In conclusion, our study was able to suggest biological markers that are non-invasive candidates to evaluate fibrosis and necroinflammatory activity in HC and HC + HSS.
Palavra-chave biological markers
hepatic fibrosis
HC
schistosomiasis
Idioma Inglês
Data de publicação 2010-07-01
Publicado em Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 105, n. 4, p. 460-466, 2010.
ISSN 0074-0276 (Sherpa/Romeo, fator de impacto)
Publicador Instituto Oswaldo Cruz, Ministério da Saúde
Extensão 460-466
Fonte http://dx.doi.org/10.1590/S0074-02762010000400018
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000281973900018
SciELO S0074-02762010000400018 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/5829

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