Functional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndrome

Functional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndrome

Author Shigaeff, Nadia Autor UNIFESP Google Scholar
Amaro, Edson Google Scholar
Franco, Fabio G. M. Google Scholar
Jacinto, Alessandro F. Autor UNIFESP Google Scholar
Chiochetta, Gabriela Autor UNIFESP Google Scholar
Cendoroglo, Maysa S. Autor UNIFESP Google Scholar
Citero, Vanessa A. Autor UNIFESP Google Scholar
Abstract Objectives: We assessed whether potential changes in brain activation patterns of elderly individuals with metabolic syndrome (MetS) who were cognitively healthy (without mild cognitive impairment or dementia) were associated with cognitive decline in executive function in the short-term. Method: We analyzed 43 individuals (23 MetS, 20 controls) using a global geriatric evaluation, a neuropsychological battery, and task-related (attention) fMRI exam. Correlation analysis between the fMRI signal at baseline and cognitive impairment after 1 year was based on the voxel-based Pearson coefficient, corrected for multiple comparisons. Results: At baseline, MetS patients showed reduced brain response in frontal and parietal regions compared to controls. After one year, the MetS group also showed a decline in verbal fluency performance. fMRI response in the right dorsolateral prefrontal cortex and bilateral parietal lobes was negatively correlated with verbal fluency decline in the MetS group. Discussion: Our results provide an early biomarker of the possible development of cognitive impairment, particularly in the executive function, of elderly individuals suffering from MetS. These findings also point to an up or down regulation which could be interpreted as compensatory mechanism for possible brain tissue burden caused by MetS.
Keywords Metabolic syndrome
Elderly
Biomarker
Neuropsychological assessment
Cognitive impairment
Functional magnetic resonance
xmlui.dri2xhtml.METS-1.0.item-coverage Clare
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Ministry of Health which, via Technical Area of Health of Aged (PROADI)
Hospital Israelita Albert Einstein under Support Program for Institutional Development of Brazilian Unified National Health System (SUS)
Grant number CAPES: 2009/12271-3
Date 2017
Published in Archives Of Gerontology And Geriatrics. Clare, v. 73, p. 1-7, 2017.
ISSN 0167-4943 (Sherpa/Romeo, impact factor)
Publisher Elsevier Ireland Ltd
Extent 1-7
Origin http://dx.doi.org/10.1016/j.archger.2017.07.002
Access rights Closed access
Type Article
Web of Science ID WOS:000413123600001
URI https://repositorio.unifesp.br/handle/11600/58283

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