EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE

EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE

Author Brianezi, Ledimar Google Scholar
Marques, Mara Rubia Google Scholar
Cardoso, Clever Gomes Google Scholar
de Jesus Miranda, Maria Luiza Google Scholar
Affonso Fonseca, Fernando Luiz Autor UNIFESP Google Scholar
Mesiano Maifrino, Laura Beatriz Google Scholar
Abstract Introduction: The emergence of coronary heart disease increases with menopause, physical inactivity and with dyslipidemia. It is known that physical training promotes the improvement of cardiovascular functions. Objective: The purpose of this study was to investigate the effects of aerobic physical training on the left ventricle in female LDL knockout ovariectomized mice. Methods: Thirty animals were divided into 6 groups (n=5), namely, sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized; sedentary ovariectomized; and trained ovariectomized. We analyzed the mean nuclear volume parameters, the cross sectional area of the myocytes, the apparent density of the capillaries, interstitium, myocytes and collagen fibers. Results: The results show that for the density of the number of nuclei, the physical activity decreased to values close to the ovariectomized control group. Regarding the mean nuclear volume and the average area of myocytes, training and ovariectomy promoted the elevation of these values but hypercholesterolemia was lower. the volume density of myocytes, hypercholesterolemia showed an increase of these values as well as the training. There was no change in the volumetric density of the capillaries and the density of collagen fibers. The training caused the decrease in the density of the interstitial volume, and the hypercholesterolemia changed to a smaller one than the control group. Conclusion: We concluded that the moderate aerobic activity or the training time used in our study were not sufficient to generate significant alterations in the hypercholesterolemic group.
Keywords heart ventricles
exercise
menopause
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo Sp
Language English
Date 2017
Published in Revista Brasileira De Medicina Do Esporte. Sao Paulo Sp, v. 23, n. 6, p. 441-445, 2017.
ISSN 1517-8692 (Sherpa/Romeo, impact factor)
Publisher Soc Brasileira Med Esporte
Extent 441-445
Origin http://dx.doi.org/10.1590/1517-869220172306160084
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000418605800003
SciELO ID S1517-86922017000600441 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/58208

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