Effects of sodium nitroprusside in the prevention of schizophrenia-like symptoms induced by ketamine - A translational double-blind study

Effects of sodium nitroprusside in the prevention of schizophrenia-like symptoms induced by ketamine - A translational double-blind study

Author Rezende, Tatiana M. N. Google Scholar
Maia-de-Oliveira, Joao Paulo Google Scholar
Kandratavicius, Ludmyla Google Scholar
Machado-de-Sousa, Joao Paulo Google Scholar
Abrao, Joao Google Scholar
Prado, Daniel Almeida Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Lacerda, Acioly L. T. Autor UNIFESP Google Scholar
Zuardi, Antonio W. Google Scholar
Baker, Glen B. Google Scholar
Dursun, Serdar M. Google Scholar
Hallak, Jaime E. C. Google Scholar
Abstract Background: Recent evidence has shown improvements in schizophrenia symptoms after the infusion of sodium nitroprusside (SNP), a nitric oxide (NO) donor. In the rat model of schizophrenia using ketamine injection, pretreatment with SNP seems to prevent behavioral changes associated with positive symptoms for up to one week. Objective: We investigated whether SNP would have preventative effects on psychogenic symptoms induced by ketamine in healthy subjects. Methods: Healthy subjects (N = 38) were assigned to distinct groups that received SNP in different doses (0.15, 0.25, and 0.5 mcg/kg/min). First, participants received an infusion of SNP or placebo over 75 minutes. After 10 minutes, they were injected for 1 minute with a bolus of 0.26 mg/kg of ketamine and a maintenance dose was started 5 minutes later, with 0.25 mg/kg/h of ketamine for 50 minutes. Results: Ketamine-induced psychopathological alterations induced were reduced by SNP, as assessed with the Brief Psychological Rating Scale. Scores in the objective subscale of the Clinician-Administered Dissociative States Scale were also lower in SNP sessions compared to placebo. SNP had protective effects against deterioration in facial emotion and identity recognition tasks induced by ketamine. Discussion: Our findings support the view that SNP has preventative properties against psychotic manifestations.
Keywords Nitric oxide
sodium nitroprusside
ketamine
schizophrenia
psychosis
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo
Language English
Date 2017
Published in Archives Of Clinical Psychiatry. Sao Paulo, v. 44, n. 6, p. 149-153, 2017.
ISSN 0101-6083 (Sherpa/Romeo, impact factor)
Publisher Univ Sao Paulo, Inst Psiquiatria
Extent 149-153
Origin http://dx.doi.org/10.1590/0101-60830000000141
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000419784600003
SciELO ID S0101-60832017000600149 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/58201

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