A cross-sectional study assessing the pharyngeal carriage of Neisseria meningitidis in subjects aged 1-24 years in the city of Embu das Artes, Sao Paulo, Brazil

A cross-sectional study assessing the pharyngeal carriage of Neisseria meningitidis in subjects aged 1-24 years in the city of Embu das Artes, Sao Paulo, Brazil

Author Weckx, Lily Yin Autor UNIFESP Google Scholar
Puccini, Rosana Fiorini Autor UNIFESP Google Scholar
Machado, Antonia Autor UNIFESP Google Scholar
Goncalves, Maria Gisele Google Scholar
Tuboi, Suely Google Scholar
de Barros, Eliana Google Scholar
Devadiga, Raghavendra Google Scholar
Ortega-Barria, Eduardo Google Scholar
Colindres, Romulo Google Scholar
Abstract Meningococcal carriage is a prerequisite for invasive infection. This cross-sectional study assessed the pharyngeal carriage prevalence in healthy subjects aged 1-24 years in Embu das Artes city, Sao Paulo, Brazil. Pharyngeal swabs were examined for the presence of Neisseria meningitidis. The isolates were tested for different serogroups using agglutination and polymerase chain reaction. A logistic regression model assessed any independent association between Neisseria meningitidis carriage and various risk factors. A total of 87/967 subjects (9%, 95% Confidence Interval (CI): 7.3-11.0) tested positive for N. meningitidis: 6.2% (95% CI: 3.8-9.4) in 1-4 years, 8.5% (95% CI: 5.1-13.0) in 5-9 years, 12.5% (95% CI: 7.8-18.6) in 10-14 years, 12.6% (95% CI: 7.4-19.7) in 15-19 years and 9% (95% CI: 4.9-14.9) in 20-24 years age groups. Highest carriage prevalence was observed in adolescents 10-19 years old. Serogroup C was predominant (18.4%) followed by serogroup B (12.6%). The 15-19 years age group showed a significant association between number of household members and carriers of N. meningitidis. This cross-sectional study is the first in Brazil to evaluate meningococcal carriage prevalence and associated factors in a wide age range. (C) 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda.
Keywords Carriage
Meningococcal disease
Neisseria meningitidis
Pharyngeal
Serogroup
xmlui.dri2xhtml.METS-1.0.item-coverage Rio De Janeiro
Language English
Sponsor GlaxoSmithKline Biologicals SA
Date 2017
Published in Brazilian Journal Of Infectious Diseases. Rio De Janeiro, v. 21, n. 6, p. 587-595, 2017.
ISSN 1413-8670 (Sherpa/Romeo, impact factor)
Publisher Elsevier Brazil
Extent 587-595
Origin http://dx.doi.org/10.1016/j.bjid.2017.06.005
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000423287700003
SciELO ID S1413-86702017000600587 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/58191

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