Anatomical specificity of the brain in the modulation of Neuroglobin and Cytoglobin genes after chronic bisphenol a exposure

Anatomical specificity of the brain in the modulation of Neuroglobin and Cytoglobin genes after chronic bisphenol a exposure

Author da Conceicao, Rodrigo Rodrigues Autor UNIFESP Google Scholar
de Souza, Janaina Sena Autor UNIFESP Google Scholar
de Oliveira, Kelen Carneiro Autor UNIFESP Google Scholar
de Barros Maciel, Rui Monteiro Autor UNIFESP Google Scholar
Romano, Marco Aurelio Google Scholar
Romano, Renata Marino Google Scholar
Dias da Silva, Magnus Regios Autor UNIFESP Google Scholar
Chiamolera, Maria Izabel Autor UNIFESP Google Scholar
Giannocco, Gisele Autor UNIFESP Google Scholar
Abstract The aim of this study was to investigate the influence of Bisphenol A (BPA) exposure on Neuroglobin (Ngb) and Cytoglobin (Cygb) as well as oxidative stress gene expression in the cerebellum, hippocampus, hypothalamus and cortex. Male Wistar rats were randomly divided into 3 groups: Control and two groups receiving 2 different daily BPA dosages, 5 or 25 mg/kg from postnatal day 50 (PND50) through PND90 and they were euthanized at PND105. In the cortex, we found an increase in Ngb gene expression and also in superoxide dismutase 1 and Catalase (Cat). In the cerebellum, we found an increase in Ngb and Cat, in the hypothalamus, there was a decrease in Cygb and an increase in glutathione peroxidase and Cat and in hypoxia-inducible factor 1 alpha (Hif1 alpha) at the low dosage and a decrease in Hif1 alpha at the high BPA dosage. Finally, in the hippocampus, we observed a decrease in Ngb and Cygb and an increase in Hif1 alpha. In summary, BPA promotes the modulation of both Ngb and Cygb, but such changes occur by different mechanisms depending on the exposure dose and anatomical area.
Keywords Bisphenola
Neuroglobin
Cytoglobin
Reactive oxygen species
Brain
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Coordenacao de Aperfeicoamento de pessoal de nivel superior (CAPES)
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
CAPES - AUXPE Pro-integracao
Grant number CAPES: 18952-12-7
FAPESP: 2013/26851-7
CAPES - AUXPE Pro-integracao: 3160/2013-98
Date 2017
Published in Metabolic Brain Disease. New York, v. 32, n. 6, p. 1843-1851, 2017.
ISSN 0885-7490 (Sherpa/Romeo, impact factor)
Publisher Springer/Plenum Publishers
Extent 1843-1851
Origin http://dx.doi.org/10.1007/s11011-017-0066-5
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000415225800007
URI https://repositorio.unifesp.br/handle/11600/58135

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