THC inhibits the expression of ethanol-induced locomotor sensitization in mice

THC inhibits the expression of ethanol-induced locomotor sensitization in mice

Author Filev, Renato Autor UNIFESP Google Scholar
Engelke, Douglas S. Google Scholar
Da Silveira, Dartiu X. Autor UNIFESP Google Scholar
Mello, Luiz E. Autor UNIFESP Google Scholar
Santos-Junior, Jair G. Google Scholar
Abstract The motivational circuit activated by ethanol leads to behavioral changes that recruit the endocannabinoid system (ECS). Case reports and observational studies suggest that the use of Cannabis sp. mitigates problematic ethanol consumption in humans. Here, we verified the effects of the two main phytocannabinoid compounds of Cannabis sp., cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), in the expression of ethanol-induced locomotor sensitization in mice. Male adult DBA/2 mice were exposed to locomotor sensitization by daily intraperitoneal injections of ethanol (2.5 g/kg) for 12 days; control groups received saline. After the acquisition phase, animals were treated with cannabinoids: CBD (2.5 mg/kg); THC (2.5 mg/kg); CBD + THC (1:1 ratio), or vehicle for 4 days with no access to ethanol during this period. One day after the last cannabinoid injection, all animals were challenged with ethanol (2.0 g/kg) to evaluate the expression of the locomotor sensitization. Mice treated with THC alone or THC + CBD showed reduced expression of locomotor sensitization, compared to the vehicle control group. No effects were observed with CBD treatment alone. Our findings showing that phytocannabinoid treatment prevents the expression of behavioral sensitization in mice provide insight into the potential therapeutic use of phytocannabinoids in alcohol-related problems. (C) 2017 Elsevier Inc. All rights reserved.
Keywords Alcohol
Cannabis
Sensitization
Dependence
Endocannabinoid system
Behavior
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Grant number FAPESP: 2009/16307-2
Date 2017
Published in Alcohol. New York, v. 65, p. 31-35, 2017.
ISSN 0741-8329 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Inc
Extent 31-35
Origin http://dx.doi.org/10.1016/j.alcohol.2017.06.004
Access rights Closed access
Type Article
Web of Science ID WOS:000415910000005
URI https://repositorio.unifesp.br/handle/11600/58120

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