LEPR polymorphism may affect energy balance during weight loss among Brazilians obese adolescents

LEPR polymorphism may affect energy balance during weight loss among Brazilians obese adolescents

Author Corgosinho, Flavia Campos Autor UNIFESP Google Scholar
Almeida, Sandro Soares Autor UNIFESP Google Scholar
Tock, Lian Google Scholar
Pesquero, Joao Bosco Autor UNIFESP Google Scholar
Araujo, Ronaldo Carvalho Autor UNIFESP Google Scholar
Grotti Clemente, Ana Paula Google Scholar
Dal'Molin Netto, Barbara Autor UNIFESP Google Scholar
da Silveira Campos, Raquel Munhoz Autor UNIFESP Google Scholar
Landi Masquio, Deborah Cristina Google Scholar
de Carvalho Ferreira, Joana Pereira Autor UNIFESP Google Scholar
Sanches, Priscila de Lima Autor UNIFESP Google Scholar
Ganen, Aline de Piano Google Scholar
Rogero, Marcelo Macedo Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
de Mello, Marco Tulio Autor UNIFESP Google Scholar
Damaso, Ana Raimunda Autor UNIFESP Google Scholar
Abstract Objective: Leptin is an adipokine released mainly by adipose tissue, with many functions including regulation of energy balance. However, little is known about the effect of LEPR polymorphism on orexigenic and anorexigenic neuropeptides. Thus, the aim of the present study is to verify the influence of LEPR polymorphism (rs2767485) on serum orexigenic (NPY, MCH and AgRP) and anorexigenic (Leptin and alpha-MSH) neuropeptides levels among obese adolescents submitted to 1 year of multicomponent weight loss therapy. Methods: Seventy-six adolescents with obesity were enrolled in 1 year of weight loss therapy including clinical, nutritional, psychological and exercise-related. Blood samples were collected to analyze neuropeptides (NPY, MCH, AgRP and leptin) and LEPR genotyping. Visceral fat was measured by ultrasound and body composition was measured by plethysmography. The parameters were measured at baseline and after one year. Adolescents were grouped according to genotype (TT or CT + CC group). Effect of the weight loss therapy was analyzed through ANOVA and Wilcox, according to normality. Statistic value was set at < 0.05. Results: C-allele carriers have the orexigenic neuropeptides (NPY, AgRP and MCH) levels statistically higher when compared with TT group, at baseline. Furthermore, TT group seems to respond better to the therapy by a greater delta on BMI. Indeed, the data suggest a concomitant increased of AgRP levels in CT + CC genotypes, after weight loss therapy. Conclusion: Both groups responded to the weight loss intervention, however wildtypes (TT) appear to respond to the intervention most optimally with C carries, where post intervention reduction in BMI was significantly greater in wildtypes. The leptin receptor polymorphism seems to affect neuroendocrine regulation of energy balance among adolescents with obesity.
Keywords Leptin
Neuropeptides
Energy balance
Obesity
Nutrigenetic
xmlui.dri2xhtml.METS-1.0.item-coverage Edinburgh
Language English
Sponsor CAPES]
FAPESP
CNPq
UNIFESP-EPM
Grant number CAPES: 12880-12-4
FAPESP: 2011/50356-0
FAPESP: 2011/50414-0
FAPESP: 2013/085226
FAPESP: 9814303-3
CNPq: 300654/2013-8
Date 2017
Published in Neuropeptides. Edinburgh, v. 66, p. 18-24, 2017.
ISSN 0143-4179 (Sherpa/Romeo, impact factor)
Publisher Churchill Livingstone
Extent 18-24
Origin http://dx.doi.org/10.1016/j.npep.2017.07.007
Access rights Closed access
Type Article
Web of Science ID WOS:000416499000003
URI https://repositorio.unifesp.br/handle/11600/58117

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account