Impact of corticotherapy, nutrition, and sleep disorder on quality of life of patients with Duchenne muscular dystrophy

Impact of corticotherapy, nutrition, and sleep disorder on quality of life of patients with Duchenne muscular dystrophy

Author Jeronimo, Giovanna Autor UNIFESP Google Scholar
Nozoe, Karen T. Autor UNIFESP Google Scholar
Polesel, Daniel N. Autor UNIFESP Google Scholar
Moreira, Gustavo A. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Abstract Duchenne muscular dystrophy (DMD) is the second most common hereditary genetic disease in humans and has elevated mortality. DMD is an X-linked, life-limiting progressive muscle-wasting disease found predominantly in boys and young men. One of the main treatments for patients with DMD is corticosteroids. However, long-term use may cause major side effects such as obesity, a reduction in vitamin D, and osteoporosis. Sleep-disordered breathing is a common condition among patients with DMD, especially obstructive sleep apnea (OSA). In children, OSA is associated with obesity and a reduction of vitamin D concentration. In this article we aim to explore the interrelationship that exists between corticosteroids, obesity, OSA, and the risk of osteoporosis. Our main hypothesis is that factors such as nutrition and sleep are related to obesity and OSA, respectively. In addition, the chronic use of corticosteroids, obesity, and OSA are factors that can reduce serum levels of vitamin D, triggering osteoporosis. Thus, these factors play a key role in affecting the quality of life for patients with DMD and intervention based on these aspects may improve survival. (C) 2016 Elsevier Inc. All rights reserved.
Keywords Duchenne muscular dystrophy
Nutrition
Sleep
Quality of life
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa
CNPq
Date 2016
Published in Nutrition. New York, v. 32, n. 3, p. 391-393, 2016.
ISSN 0899-9007 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Inc
Extent 391-393
Origin http://dx.doi.org/10.1016/j.nut.2015.09.004
Access rights Closed access
Type Article
Web of Science ID WOS:000370312300015
URI https://repositorio.unifesp.br/handle/11600/57933

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