Resveratrol improves reproductive parameters of adult rats varicocelized in peripuberty

Resveratrol improves reproductive parameters of adult rats varicocelized in peripuberty

Author Mendes, Talita Biude Autor UNIFESP Google Scholar
Paccola, Camila Cicconi Autor UNIFESP Google Scholar
de Oliveira Neves, Flavia Macedo Autor UNIFESP Google Scholar
Simas, Joana Nogueres Autor UNIFESP Google Scholar
Vaz, Andre da Costa Autor UNIFESP Google Scholar
Cabral, Regina Elisabeth L. Autor UNIFESP Google Scholar
Vendramini, Vanessa Autor UNIFESP Google Scholar
Miraglia, Sandra Maria Autor UNIFESP Google Scholar
Abstract The aim of this study was to investigate the protective action of resveratrol against the reproductive damage caused by left-sided experimental varicocele. There was a reduction of testicular major axis in the varicocele group when compared with the other groups

the testicular volume was reduced in varicocele group in comparison to the sham-control and resveratrol groups. The frequency of morphologically abnormal sperm was higher in varicocele and varicocele treated with resveratrol groups than in sham-control and resveratrol groups. The frequency of sperm with 100% of mitochondrial activity and normal acrosome integrity were lower in varicocele group than in varicocele treated with resveratrol, sham-control and resveratrol groups. Sperm motility was also reduced in varicocele group than in other groups. The sperm DNA fragmentation was higher in varicocele group than in other groups. Testicular levels of malondialdehyde were higher in varicocele and varicocele treated with resveratrol groups. The varicocele and varicocele treated with resveratrol groups had a significantly higher frequency of TUNEL-positive cells than sham-control and resveratrol groups

however, immunolabeling of the testes from varicocele treated with resveratrol group showed a lower number of apoptotic germ cells in comparison with the left testis of rats of the varicocele group. Reproductive alterations produced by varicocele from peripuberty were reduced by resveratrol in adulthood. Resveratrol should be better investigated as an adjuvant in the treatment of varicocele. Daily administration of resveratrol to rats with varicocele from peripuberty improves sperm quality in the adulthood.
xmlui.dri2xhtml.METS-1.0.item-coverage Bristol
Language English
Sponsor National Council for the Improvement of Higher Education (CAPES/Brazil)
Laboratory of Human Reproduction - Unifesp
Date 2016
Published in Reproduction. Bristol, v. 152, n. 1, p. 23-35, 2016.
ISSN 1470-1626 (Sherpa/Romeo, impact factor)
Publisher Bioscientifica Ltd
Extent 23-35
Origin http://dx.doi.org/10.1530/REP-16-0025
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000379551900006
URI https://repositorio.unifesp.br/handle/11600/57676

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