Does hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients?

Does hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients?

Author de Melo, Daniela Oliveira Autor UNIFESP Google Scholar
Storpirtis, Silvia Google Scholar
Ribeiro, Eliane Google Scholar
Abstract The purpose of the work was to assess the incidence of potential drug interactions (pDDI), major pDDI, and the use of potentially inappropriate medication (PIM) at hospital admission, during hospitalization, and at discharge to evaluate whether hospital admission provides an opportunity for improving pharmacotherapy in elderly patients at a University hospital that has a clinical pharmacist. A prospective cohort study was carried out using data from the medical records of patients admitted to an internal medicine ward. All admissions and prescriptions were monitored between March and August 2006. Micromedex (R) DrugReax (R) and Beers Criteria 2015 were used to identify pDDI, major pDDI, and PIMs, respectively. A comparison of admission and discharge prescriptions showed the following: an increase in the proportion of patients using antithrombotic agents (76 versus 144; p< 0.001), lipid modifying agents (58 versus 81; p= 0.024), drugs for acid-related disorders (99 versus 152; p< 0.001), and particularly omeprazole (61 versus 87; p= 0.015); a decrease in the number of patients prescribed psycholeptics (73 versus 32; p< 0.001) and diazepam (54 versus 13; p< 0.001); and a decrease in the proportion of patients exposed to polypharmacy (16.1% versus 10.1%; p= 0.025), at least one pDDI (44.5% versus 32.8%; p= 0.002), major pDDI (19.9% versus 12.2%; p= 0.010) or PIM (85.8% versus 51.9%; p< 0.001). The conclusion is that admission to a hospital ward that has a clinical pharmacist was associated with a reduction in the number of patients exposed to polypharmacy, pDDI, major pDDI, and the use of PIMs among elderly inpatients.
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo
Language English
Sponsor School of Pharmaceutical Sciences and the University Hospital of the University of Sao Paulo
Coordination for the Improvement of Higher Education Personnel (CAPES)
Grant number CAPES: 140956/2006-9
Date 2016
Published in Brazilian Journal Of Pharmaceutical Sciences. Sao Paulo, v. 52, n. 3, p. 391-401, 2016.
ISSN 1984-8250 (Sherpa/Romeo, impact factor)
Publisher Univ Sao Paulo, Conjunto Quimicas
Extent 391-401
Origin http://dx.doi.org/10.1590/S1984-82502016000300005
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000390332400005
SciELO ID S1984-82502016000300391 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/57565

Show full item record




File

Name: WOS000390332400005.pdf
Size: 374.3Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account