Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation

Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation

Author Sato, Joao Ricardo Autor UNIFESP Google Scholar
Biazoli, Claudinei Eduardo, Jr. Google Scholar
Salum, Giovanni Abrahao Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Crossley, Nicolas Google Scholar
Vieira, Gilson Google Scholar
Zugman, Andre Autor UNIFESP Google Scholar
Picon, Felipe Almeida Google Scholar
Pan, Pedro Mario Autor UNIFESP Google Scholar
Hoexter, Marcelo Queiroz Autor UNIFESP Google Scholar
Anes, Mauricio Google Scholar
Moura, Luciana Monteiro Autor UNIFESP Google Scholar
Gomes Del'Aquilla, Marco Antonio Autor UNIFESP Google Scholar
Amaro Junior, Edson Google Scholar
Mcguire, Philip Google Scholar
Rohde, Luis Augusto Google Scholar
Miguel, Euripedes Constantino Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Jackowski, Andrea Parolin Autor UNIFESP Google Scholar
Abstract Functional brain hubs are key integrative regions in brain networks. Recently, brain hubs identified through resting-state fMRI have emerged as interesting targets to increase understanding of the relationships between large-scale functional networks and psychopathology. However, few studies have directly addressed the replicability and consistency of the hub regions identified and their association with symptoms. Here, we used the eigenvector centrality (EVC) measure obtained from graph analysis of two large, independent population-based samples of children and adolescents (7-15 years old

total N = 652

341 subjects for site 1 and 311 for site 2) to evaluate the replicability of hub identification. Subsequently, we tested the association between replicable hub regions and psychiatric symptoms. We identified a set of hubs consisting of the anterior medial prefrontal cortex and inferior parietal lobule/intraparietal sulcus (IPL/IPS). Moreover, lower EVC values in the right IPS were associated with psychiatric symptoms in both samples. Thus, low centrality of the IPS was a replicable sign of potential vulnerability to mental disorders in children. The identification of critical and replicable hubs in functional cortical networks in children and adolescents can foster understanding of the mechanisms underlying mental disorders. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
Keywords Resting state
Replication
fMRI
Connectivity
Development
Children
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor Sao Paulo Research Foundation - FAPESP
National Institutes of Science and Technology for Developmental Psychiatry of Children and Adolescents (INPD) - CNPq
FAPESP
CAPES-Brazil
CNPq-Brazil
Grant number FAPESP: 2013/10498-6
FAPESP: 2013/00506-1
FAPESP: 2013/08531-5
National Institutes of Science and Technology for Developmental Psychiatry of Children and Adolescents (INPD) - CNPq: 573974/2008-0
National Institutes of Science and Technology for Developmental Psychiatry of Children and Adolescents (INPD) - CNPq: 442026/2014-5
FAPESP: 2008/57896-8
Date 2016
Published in Developmental Cognitive Neuroscience. Oxford, v. 20, p. 2-11, 2016.
ISSN 1878-9293 (Sherpa/Romeo, impact factor)
Publisher Elsevier Sci Ltd
Extent 2-11
Origin http://dx.doi.org/10.1016/j.dcn.2016.05.002
Access rights Closed access
Type Article
Web of Science ID WOS:000380847600002
URI https://repositorio.unifesp.br/handle/11600/57481

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