Low-Level Laser Therapy (780 nm) on VEGF Modulation at Partially Injured Achilles Tendon

Low-Level Laser Therapy (780 nm) on VEGF Modulation at Partially Injured Achilles Tendon

Author de Jesus, Julio Fernandes Google Scholar
Spadacci-Morena, Diva Denelle Google Scholar
dos Anjos Rabelo, Nayra Deise Google Scholar
Pinfildi, Carlos Eduardo Autor UNIFESP Google Scholar
Fukuda, Thiago Yukio Google Scholar
Plapler, Helio Autor UNIFESP Google Scholar
Abstract Objective: The aim of this study was to analyze the modulatory effects of near infrared (780 nm) low-level laser therapy (LLLT) on the presence of the vascular endothelial growth factor (VEGF) in the partially injured Achilles tendons of rats. Background: LLLT stimulates the healing process for Achilles tendon injuries, although the extent of the modulatory effect of LLLT on the VEGF levels found in the injured tendons remains unclear. Methods: Sixty-five male Wistar rats were distributed in the following seven groups: LASER 1, 3, and 7 (10 partially injured Achilles tendons in each group, which were treated with LLLT for 1, 3, and 7 days, respectively)

Sham 1, 3, and 7 (same injury, with simulated LLLT)

Control group containing the five remaining animals and in which no procedures were performed. LLLT was applied once a day for 10 sec, with a mean power of 70mW and fluency of 17.5 J/cm(2). After euthanasia, all of the Achilles tendons were surgically removed and the VEGF levels were analyzed using immunohistochemistry. Results: The VEGF levels remained close to normal (p > 0.05) when comparing the experimental groups (LASER and Sham: 1, 3, and 7) with the Control group. Conclusion: LLLT did not stimulate the expression of VEGF in the treated Achilles tendons.
xmlui.dri2xhtml.METS-1.0.item-coverage New Rochelle
Language English
Sponsor Sao Paulo Research Foundation (FAPESP)
Grant number FAPESP: 2011/00979-1
Date 2016
Published in Photomedicine And Laser Surgery. New Rochelle, v. 34, n. 8, p. 331-335, 2016.
ISSN 1549-5418 (Sherpa/Romeo, impact factor)
Publisher Mary Ann Liebert, Inc
Extent 331-335
Origin http://dx.doi.org/10.1089/pho.2016.4092
Access rights Closed access
Type Article
Web of Science ID WOS:000381215800006
URI https://repositorio.unifesp.br/handle/11600/57460

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