Not All Children with Cystic Fibrosis Have Abnormal Esophageal Neutralization during Chemical Clearance of Acid Reflux

Not All Children with Cystic Fibrosis Have Abnormal Esophageal Neutralization during Chemical Clearance of Acid Reflux

Author Woodley, Frederick W. Google Scholar
Moore-Clingenpeel, Melissa Google Scholar
Machado, Rodrigo Strehl Autor UNIFESP Google Scholar
Nemastil, Christopher J. Google Scholar
Jadcherla, Sudarshan R. Google Scholar
Hayes, Don, Jr. Google Scholar
Kopp, Benjamin T. Google Scholar
Kaul, Ajay Google Scholar
Di Lorenzo, Carlo Google Scholar
Mousa, Hayat Google Scholar
Abstract Purpose: Acid neutralization during chemical clearance is significantly prolonged in children with cystic fibrosis, compared to symptomatic children without cystic fibrosis. The absence of available reference values impeded identification of abnormal findings within individual patients with and without cystic fibrosis. The present study aimed to test the hypothesis that significantly more children with cystic fibrosis have acid neutralization durations during chemical clearance that fall outside the physiological range. Methods: Published reference value for acid neutralization duration during chemical clearance (determined using combined impedance/pH monitoring) was used to assess esophageal acid neutralization efficiency during chemical clearance in 16 children with cystic fibrosis (3 to< 18 years) and 16 age-matched children without cystic fibrosis. Results: Duration of acid neutralization during chemical clearance exceeded the upper end ofthe physiological range in 9 of 16 (56.3%) children with and in 3 of 16 (18.8%) children without cystic fibrosis (p=0.0412). The likelihood ratio for duration indicated that children with cystic fibrosis are 2.1-times more likely to have abnormal acid neutralization during chemical clearance, and children with abnormal acid neutralization during chemical clearance are 1.5-times more likely to have cystic fibrosis. Conclusion: Significantly more (but not all) children with cystic fibrosis have abnormally prolonged esophageal clearance of acid. Children with cystic fibrosis are more likely to have abnormal acid neutralization during chemical clearance. Additional studies involving larger sample sizes are needed to address the importance of genotype, esophageal motility, composition and volume of saliva, and gastric acidity on acid neutralization efficiency in cystic fibrosis children.
Keywords Chemical clearance
Acid neutralization
Impedance
Cystic fibrosis
Child
xmlui.dri2xhtml.METS-1.0.item-coverage Seoul
Language English
Date 2017
Published in Pediatric Gastroenterology Hepatology & Nutrition. Seoul, v. 20, n. 3, p. 153-159, 2017.
ISSN 2234-8646 (Sherpa/Romeo, impact factor)
Publisher Korean Soc Pediatric Gastroenterology & Nutrition
Extent 153-159
Origin http://dx.doi.org/10.5223/pghn.2017.20.3.153
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000418531900003
URI https://repositorio.unifesp.br/handle/11600/57387

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