Antioxidant and cytotoxic activity of propolis of Plebeia droryana and Apis mellifera (Hymenoptera, Apidae) from the Brazilian Cerrado biome

Antioxidant and cytotoxic activity of propolis of Plebeia droryana and Apis mellifera (Hymenoptera, Apidae) from the Brazilian Cerrado biome

Author Bonamigo, Thaliny Google Scholar
Campos, Jaqueline Ferreira Google Scholar
Oliveira, Alex Santos Google Scholar
Vieira Torquato, Heron Fernandes Autor UNIFESP Google Scholar
Perrella Balestieri, Jose Benedito Google Scholar
Lima Cardoso, Claudia Andrea Google Scholar
Paredes-Gamero, Edgar Julian Google Scholar
Souza, Kely de Picoli Google Scholar
dos Santos, Edson Lucas Google Scholar
Abstract Propolis is a complex bioactive mixture produced by bees, known to have different biological activities, especially in countries where there is a rich biodiversity of plant species. The objective of this study was to determine the chemical composition and evaluate the antioxidant and cytotoxic properties of Brazilian propolis from the species Plebeia droryana and Apis mellifera found in Mato Grosso do Sul, Brazil. In the ethanolic extracts of P. droryana propolis (ExEP-P) and A. mellifera (ExEP-A) acids, phenolic compounds, terpenes and tocopherol were identified as major compounds. Both extracts presented antioxidant activity against the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, the maximum activities being 500 mu g/mL (ExEP-P) and 300 mu g/mL (ExEP-A). However, only ExEP-A was able to inhibit lipid peroxidation induced by the oxidizing agent 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH), which inhibited oxidative hemolysis and reduced the levels of malondialdehyde (MDA) in human erythrocytes for 4 h of incubation. The extracts also reduced the cell viability of the K562 erythroleukemia tumour line, with a predominance of necrotic death. Thus, it is concluded that the propolis produced by P. droryana and A. mellifera contain important compounds capable of minimizing the action of oxidizing substances in the organism and reducing the viability of erythroleukemia cells.
xmlui.dri2xhtml.METS-1.0.item-coverage San Francisco
Language English
Sponsor Development of Education, Science and Technology of Mato Grosso do Sul State - FUNDECT
Brazilian National Research Council - CNPq
Instituto Nacional de Pesquisa do Pantanal - INPP
Fundacao de Amparo e Desenvolvimento da Pesquisa - Fadesp
Date 2017
Published in Plos One. San Francisco, v. 12, n. 9, p. -, 2017.
ISSN 1932-6203 (Sherpa/Romeo, impact factor)
Publisher Public Library Science
Extent -
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000410449500009

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