Chia (Salvia hispanica L.) flour promotes beneficial effects on adipose tissue but not on glycaemic profile of diet-induced obesity in mice

Chia (Salvia hispanica L.) flour promotes beneficial effects on adipose tissue but not on glycaemic profile of diet-induced obesity in mice

Author Carnier, June Autor UNIFESP Google Scholar
Silva, Fernanda Pinheiro Autor UNIFESP Google Scholar
de Miranda, Danielle Araujo Autor UNIFESP Google Scholar
Santamarina, Aline Boveto Autor UNIFESP Google Scholar
Mennitti, Lais Vales Autor UNIFESP Google Scholar
Moreira, Renata Guimaraes Google Scholar
Oller do Nascimento, Claudia Maria Autor UNIFESP Google Scholar
Ribeiro, Eliane Beraldi Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Abstract This study evaluated effects of integral chia flour (Salvia hispanica L.) associated with high-fat diet on glucose metabolism, fatty acid profile, and inflammatory mediators in epididymal adipose and liver tissue using experimental obesity models induced by high-calorie and -fat diets. Forty-eight mice were divided into four experimental groups: control diet (C)

control diet+chia flour (CCh)

high-fat and -calorie diet (H), and high-fat and -calorie diet+chia flour (HCh). Tissue cytokines, fatty acid profile, and glycaemic profile were measured. In oral glucose tolerance testing, HCh presented higher glycaemia than H at 15, 30, and 120min. In epididymal adipose tissue, CCh showed higher accumulation of alpha-linolenic fatty acid (-LNA) than C, while HCh showed higher accumulation of -LNA and lower concentrations of C20:4n6 fatty acid than H. In liver tissue, CCh presented higher accumulation of -LNA and lower concentrations of C20:4n6 fatty acid than C. We believe that 12g of chia flour per kg of food for 10wk is essential for prevention and treatment of obesity

however, it may be necessary to adjust chia amounts and treatment times to improve glycaemic profiles. This study provides pioneering results on the effects of chia in mice. Practical applications: With the hope of losing weight and becoming healthier, many people adopt radical diets that can be harmful to their health. Accordingly, dietary guidelines must be carefully planned by qualified health professionals, especially considering the comorbidities of diabetes and cardiovascular disease that accompany obesity. In addition, the adequate treatment of obesity increases the chances of the patients maintaining their diet and lifestyle changes, thus, allowing for greater control of their obesity. Consequently, knowledge of the appropriate dosages and effects of chia is important for the development of new tools for composing dietary guidelines for healthy individuals, especially for the treatment of obese patients. Effects of chia flour (Salvia hispanica L.) on liver tissue fatty acid (A) and epididymal adipose tissue fatty acid (B) of all groups after treatment. Data are expressed as mean +/- S.E. *, statistical difference of C group

#, statistical difference of CCh group

, statistical difference of H group (p<0.05).
Keywords Chia
Fatty acid
Glucose metabolism
Inflammation
Obesity
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor FAPESP (Fundacao de Apoio a Pesquisa do Estado de Sao Paulo)
Grant number FAPESP: 2013/12410-9
Date 2017
Published in European Journal Of Lipid Science And Technology. Hoboken, v. 119, n. 10, p. -, 2017.
ISSN 1438-7697 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent -
Origin http://dx.doi.org/10.1002/ejlt.201600384
Access rights Closed access
Type Article
Web of Science ID WOS:000412122500004
URI https://repositorio.unifesp.br/handle/11600/57323

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