Involvement of the prelimbic cortex in contextual fear conditioning with temporal and spatial discontinuity

Involvement of the prelimbic cortex in contextual fear conditioning with temporal and spatial discontinuity

Author Santos, Thays Brenner Autor UNIFESP Google Scholar
Kramer-Soares, Juliana Carlota Autor UNIFESP Google Scholar
Favaro, Vanessa Manchim Autor UNIFESP Google Scholar
Menezes Oliveira, Maria Gabriela Autor UNIFESP Google Scholar
Abstract Time plays an important role in conditioning, it is not only possible to associate stimuli with events that overlap, as in delay fear conditioning, but it is also possible to associate stimuli that are discontinuous in time, as shown in trace conditioning for a discrete stimuli. The environment itself can be a powerful conditioned stimulus (CS) and be associated to unconditioned stimulus (US). Thus, the aim of the present study was to determine the parameters in which contextual fear conditioning occurs by the maintenance of a contextual representation over short and long time intervals. The results showed that a contextual representation can be maintained and associated after 5 s, even in the absence of a 15 s re-exposure to the training context before US delivery. The same effect was not observed with a 24 h interval of discontinuity. Furthermore, optimal conditioned response with a 5 s interval is produced only when the contexts (of pre-exposure and shock) match. As the pre-limbic cortex (PL) is necessary for the maintenance of a continuous representation of a stimulus, the involvement of the PL in this temporal and contextual processing was investigated. The reversible inactivation of the PL by muscimol infusion impaired the acquisition of contextual fear conditioning with a 5 s interval, but not with a 24 h interval, and did not impair delay fear conditioning. The data provided evidence that short and long intervals of discontinuity have different mechanisms, thus contributing to a better understanding of PL involvement in contextual fear conditioning and providing a model that considers both temporal and contextual factors in fear conditioning. (C) 2017 Elsevier Inc. All rights reserved.
Keywords Memory
Contextual fear conditioning
Trace conditioning
Medial prefrontal cortex
Prelimbic cortex
xmlui.dri2xhtml.METS-1.0.item-coverage San Diego
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, FAPESP [2013/24576-9]
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, CNPq
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Associacao de Fundo de Incentivo a Pesquisa (AFIP)
Grant number FAPESP: 2013/24576-9
Date 2017
Published in Neurobiology Of Learning And Memory. San Diego, v. 144, p. 1-10, 2017.
ISSN 1074-7427 (Sherpa/Romeo, impact factor)
Publisher Academic Press Inc Elsevier Science
Extent 1-10
Access rights Closed access
Type Article
Web of Science ID WOS:000411168800002

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