Microbiota abnormalities and the therapeutic potential of probiotics in the treatment of mood disorders

Microbiota abnormalities and the therapeutic potential of probiotics in the treatment of mood disorders

Author Rios, Adiel C. Autor UNIFESP Google Scholar
Maurya, Pawan Kumar Autor UNIFESP Google Scholar
Pedrini, Mariana Autor UNIFESP Google Scholar
Zeni-Graiff, Maiara Autor UNIFESP Google Scholar
Asevedo, Elson Autor UNIFESP Google Scholar
Mansur, Rodrigo B. Google Scholar
Wieck, Andrea Google Scholar
Grassi-Oliveira, Rodrigo Google Scholar
McIntyre, Roger S. Google Scholar
Hayashi, Mirian A. F. Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Abstract Major depressive disorder (MDD) and bipolar disorder (BD) are among the leading causes of burden and disability worldwide. Despite intensified research efforts to improve the treatment options and remission rates in mood disorders, no disease modifying treatment exists for these disorders. Accumulating evidence implicates the involvement of the gut microbiota in processes relevant to etiopathology of central nervous system-based disorders. The objective of this article was to critically evaluate the evidence supporting the link between gastrointestinal microbiota and mood disorders and to discuss the potential benefits of using probiotics in the treatment of MDD and BD. The concept of psychobiotics, which is bacterial-based interventions with mental health benefit, is emerging in the field. On the other hand, while probiotics might potentially represent a significant advance, specific roles of microbiota in the pathophysiology of mood disorders still need further investigation along with intervention studies.
Keywords bipolar disorder
major depression disorder
microbiome
microbiota
mood disorders
probiotics
xmlui.dri2xhtml.METS-1.0.item-coverage Berlin
Language English
Sponsor coordination of the Improvement of Higher Education Personnel (CAPES), Brazil
National Council of Technological and Scientific Development (CNPq), Brazil
Date 2017
Published in Reviews In The Neurosciences. Berlin, v. 28, n. 7, p. 739-749, 2017.
ISSN 0334-1763 (Sherpa/Romeo, impact factor)
Publisher Walter De Gruyter Gmbh
Extent 739-749
Origin http://dx.doi.org/10.1515/revneuro-2017-0001
Access rights Closed access
Type Article
Web of Science ID WOS:000412280400005
URI https://repositorio.unifesp.br/handle/11600/57300

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