Effects of acute physical exercise in the light phase of sleep in rats with temporal lobe epilepsy

Effects of acute physical exercise in the light phase of sleep in rats with temporal lobe epilepsy

Author Autor UNIFESP Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Polesel, Daniel Ninello Autor UNIFESP Google Scholar
Fernandes de Alvarenga, Tathiana Aparecida Autor UNIFESP Google Scholar
Vancini, Rodrigo Luiz Google Scholar
Matos, Gabriela Autor UNIFESP Google Scholar
Tufika, Sergio Autor UNIFESP Google Scholar
Abstract Objective: Our aim was to investigate the influence of an acute exercise session on sleep pattern in rats with temporal lobe epilepsy (TLE). Methods: Twenty male Wistar rats were randomly assigned to 4 groups: control (C)

acute exercise (EX)

epilepsy (E) and epilepsy acute exercise (EEX). Two sleep electrocorticography recordings were performed during the light phase [baseline and day 2 (after the acute physical exercise session)]. After baseline recording, the exercise groups (EX and EEX) were submitted to an exercise session on a motor-driven treadmill at 12 m/min for 30 min. Twelve hours later, the rats were submitted to the second sleep recording. Results: At baseline, the E group showed a higher wakefulness and a lower Total sleep time, Slow Wave Sleep and REM sleep compared with the C group. After acute exercise, there was an increase in Total sleep time and Slow Wave Sleep and a decrease of wakefulness in EEX (+11.10%, +20.29% and -11.25%, respectively) and EX (+5.20%, +11.60% and 8.12%, respectively) groups. Conclusion: These findings suggest that acute physical exercise positively impacts the sleep pattern of rats with TLE, inducing a more consolidated sleep.
Keywords Epilepsy
Temporal lobe epilepsy
Physical exercise
Sleep and electrocorticogram
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor AFIP
CAPES
CNPq
FAPESP
Date 2017
Published in Epilepsy Research. Amsterdam, v. 136, p. 54-61, 2017.
ISSN 0920-1211 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 54-61
Origin http://dx.doi.org/10.1016/j.eplepsyres.2017.07.012
Access rights Closed access
Type Article
Web of Science ID WOS:000412255800007
URI https://repositorio.unifesp.br/handle/11600/57272

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