Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls

Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls

Author Matsuzaka, Camila T. Autor UNIFESP Google Scholar
Christofolini, Denise Google Scholar
Ota, Vanessa K. Autor UNIFESP Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Berberian, Arthur A. Autor UNIFESP Google Scholar
Noto, Cristiano Autor UNIFESP Google Scholar
Mazzotti, Diego R. Autor UNIFESP Google Scholar
Spindola, Leticia M. Autor UNIFESP Google Scholar
Moretti, Patricia N. Autor UNIFESP Google Scholar
Smith, Marilia A. C. Autor UNIFESP Google Scholar
Melaragno, Maria I. Autor UNIFESP Google Scholar
Belangero, Sintia I. Autor UNIFESP Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Abstract Objective: Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC). It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship between cognition and dopamine activity in the PFC. Other COMT SNPs could also play a role. Methods: We evaluated the role of three COMT SNPs (rs737865, rs165599, and rs4680) in schizophrenia and their impact on three working memory tasks. For genetic association analyses, 212 individuals with schizophrenia and 257 healthy controls (HCs) were selected. The Visual Working Memory (VWM) Task, Keep Track Task, and Letter Memory Task were administered to 133 schizophrenics and 93 HCs. Results: We found a significant association of rs737865, with the GG genotype exerting a protective effect and the GA haplotype (rs4680/rs165599) exerting a risk effect for schizophrenia. COMT rs4680 AA carriers and rs737865 AA carriers scored lowest on the Keep Track Task. When the genotype* group interaction effect was evaluated, rs165599 exerted opposite effects for VWM and Keep Track task performance in patients and controls, with AA carriers scoring lowest on both tests among controls, but highest among patients. Conclusion: These data support the hypothesis that COMT polymorphisms may be associated with schizophrenia and modulate cognition in patients and controls.
Keywords Cognition
dopamine
gene
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil
Grant number FAPESP: 2007/58736-1
FAPESP: 2011/50740-5
Date 2017
Published in Revista Brasileira De Psiquiatria. Sao Paulo, v. 39, n. 4, p. 302-308, 2017.
ISSN 1516-4446 (Sherpa/Romeo, impact factor)
Publisher Assoc Brasileira Psiquiatria
Extent 302-308
Origin http://dx.doi.org/10.1590/1516-4446-2016-1987
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000415387500006
SciELO ID S1516-44462017000400302 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/57225

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