Single-nucleotide polymorphisms in genes related to the hypothalamic-pituitary-adrenal axis as risk factors for posttraumatic stress disorder

Single-nucleotide polymorphisms in genes related to the hypothalamic-pituitary-adrenal axis as risk factors for posttraumatic stress disorder

Author Carvalho, Carolina M Autor UNIFESP Google Scholar
Coimbra, Bruno M. Autor UNIFESP Google Scholar
Ota, Vanessa K. Autor UNIFESP Google Scholar
Mello, Marcelo F. Autor UNIFESP Google Scholar
Belangero, Sintia I. Autor UNIFESP Google Scholar
Abstract Posttraumatic stress disorder (PTSD) is a common psychiatric disorder. The etiology of PTSD is multifactorial, depending on many environmental and genetic risk factors, and the exposure to life or physical integrity-threatening events. Several studies have shown significant correlations of many neurobiological findings with PTSD. Hypothalamic-pituitary-adrenal (HPA) axis dysfunction is strongly correlated with this disorder. One hypothesis is that HPA axis dysfunction may precede the traumatic event, suggesting that genes expressed in the HPA axis may be involved in the development of PTSD. This article reviews molecular genetic studies related to PTSD collected through a literature search performed in PubMed, MEDLINE, ScienceDirect, and Scientific Electronic Library Online (SciELO). The results of these studies suggest that several polymorphisms in the HPA axis genes, including FKBP5, NR3C1, CRHR1, and CRHR2, may be risk factors for PTSD development or may be associated with the severity of PTSD symptoms.
Keywords gene
HPA axis
polymorphisms
PTSD
trauma
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP 2014/12559-5, 07280-1]
Grant number FAPESP: 2014/12559-5
FAPESP: 2014/07280-1]
Date 2017
Published in American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics. Hoboken, v. 174, n. 7, p. 671-682, 2017.
ISSN 1552-4841 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent 671-682
Origin http://dx.doi.org/10.1002/ajmg.b.32564
Access rights Closed access
Type Article
Web of Science ID WOS:000417426700002
URI https://repositorio.unifesp.br/handle/11600/57201

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account