Exposure to crack cocaine causes adverse effects on marine mussels Perna perna

Exposure to crack cocaine causes adverse effects on marine mussels Perna perna

Author Maranho, L. A. Autor UNIFESP Google Scholar
Fontes, M. K. Autor UNIFESP Google Scholar
Kamimura, A. S. S. Google Scholar
Nobre, C. R. Google Scholar
Moreno, B. B. Autor UNIFESP Google Scholar
Pusceddu, F. H. Google Scholar
Cortez, F. S. Google Scholar
Lebre, D. T. Google Scholar
Marques, J. R. Google Scholar
Abessa, D. M. S. Google Scholar
Ribeiro, D. A. Autor UNIFESP Google Scholar
Pereira, C. D. S. Autor UNIFESP Google Scholar
Abstract Our study aimed to evaluate crack cocaine effects in different life stages of the marine mussel Perna perm. For this purpose, fertilization rate, embryo-larval development, lysosomal membrane stability and DNA strand breaks were assessed. Effect concentrations in gametes and in larval development were found after 1 h (IC50 = 23.53 mg.L-1) and 48 h (IC50 = 16.31 mg.L-1),respectively. The highest tested concentration showing no acute toxicity (NOEC) was 10 mg.L-1, while the lowest observed effect concentration (LOEC) was 20 mg.L-1. NOEC concerning embryo-larval development was 0.625 mg.L-1, while the LOEC was 1.25 mg.L-1. Cyto-genotoxic effects were evidenced in mussels exposed to crack cocaine concentrations ranging from 5 to 500 mu g.L-1. Our results report the first data on effects of an illicit drug to marine organisms and should encourage further ecotoxicological studies of these contaminants of emerging concern in coastal ecosystems.
Keywords Crack cocaine
Bioassays
Cyto-genotoxicity
Marine organism
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor Sao Paulo Research Foundation (FAPESP)
CNPq
Grant number FAPESP: 2015/17329-0
CNPq: 402931/2015-7
Date 2017
Published in Marine Pollution Bulletin. Oxford, v. 123, n. 43497, p. 410-414, 2017.
ISSN 0025-326X (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 410-414
Origin http://dx.doi.org/10.1016/j.marpolbul.2017.08.043
Access rights Closed access
Type Article
Web of Science ID WOS:000415776600061
URI https://repositorio.unifesp.br/handle/11600/57144

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