Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients

Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients

Autor Rasmussen, Lucas Trevizani Autor UNIFESP Google Scholar
Lábio, Roger Willian de Google Scholar
Gatti, Luciano Lobo Google Scholar
Silva, Luiz Carlos da Google Scholar
Queiroz, Valdeir Fagundes de Google Scholar
Smith, Marilia de Arruda Cardoso Autor UNIFESP Google Scholar
Payão, Spencer Luiz Marques Autor UNIFESP Google Scholar
Instituição Universidade do Sagrado Coração
Faculdade de Medicina de Marília Hemocentro
Faculdades Integradas de Ourinhos
Faculdade de Medicina de Marília
Universidade Federal de São Paulo (UNIFESP)
Resumo Helicobacter pylori is an important human pathogen that causes chronic gastritis and is associated with the development of peptic ulcer disease and gastric malignancies. The oral cavity has been implicated as a potential H. pylori reservoir and may therefore be involved in the reinfection of the stomach, which can sometimes occur following treatment of an H. pylori infection. The objectives of this paper were (i) to determine the presence of H. pylori in the oral cavity and (ii) to examine the relationship between oral H. pylori and subsequent gastritis. Gastric biopsies, saliva samples and dental plaques were obtained from 78 dyspeptic adults. DNA was extracted and evaluated for the presence of H. pylori using polymerase chain reaction and Southern blotting methods. Persons with gastritis were frequently positive for H. pylori in their stomachs (p < 0.0001) and there was a statistically significant correlation between the presence of H. pylori in gastric biopsies and the oral cavity (p < 0.0001). Our results suggest a relationship between gastric infection and the presence of this bacterium in the oral cavity. Despite this, H. pylori were present in the oral cavity with variable distribution between saliva and dental plaques, suggesting the existence of a reservoir for the species and a potential association with gastric reinfection.
Palavra-chave Helicobacter pylori
oral infection
saliva
dental plaque
Idioma Inglês
Data de publicação 2010-05-01
Publicado em Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 105, n. 3, p. 326-330, 2010.
ISSN 0074-0276 (Sherpa/Romeo)
Publicador Instituto Oswaldo Cruz, Ministério da Saúde
Extensão 326-330
Fonte http://dx.doi.org/10.1590/S0074-02762010000300015
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S0074-02762010000300015 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/5713

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