Serum copeptin in children exposed to maltreatment

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dc.contributor.author Coelho, Roberta
dc.contributor.author Levandowski, Mateus L.
dc.contributor.author Mansur, Rodrigo B.
dc.contributor.author Cunha, Graccielle Rodrigues da [UNIFESP]
dc.contributor.author Asevedo, Elson [UNIFESP]
dc.contributor.author Zugman, Andre [UNIFESP]
dc.contributor.author Salum, Giovanni A.
dc.contributor.author Gadelha, Ary [UNIFESP]
dc.contributor.author Pan, Pedro Mario [UNIFESP]
dc.contributor.author Rizzo, Lucas Bortolotto [UNIFESP]
dc.contributor.author Manfro, Gisele
dc.contributor.author Mari, Jair de Jesus [UNIFESP]
dc.contributor.author Rohde, Luis A.
dc.contributor.author Miguel, Euripedes C.
dc.contributor.author Bressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.author Brietzke, Elisa [UNIFESP]
dc.contributor.author Grassi-Oliveira, Rodrigo
dc.date.accessioned 2020-07-31T12:47:41Z
dc.date.available 2020-07-31T12:47:41Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1111/pcn.12412
dc.identifier.citation Psychiatry And Clinical Neurosciences. Hoboken, v. 70, n. 10, p. 434-441, 2016.
dc.identifier.issn 1323-1316
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/56999
dc.description.abstract AimChildhood maltreatment (CM) has been related to a persistent reprograming of stress-response. Copeptin is a marker of hypothalamic-pituitary-adrenal axis activation en
dc.description.abstract however, few studies have examined copeptin levels in children exposed to CM. The aim of this study was to compare serum copeptin levels in children reporting child abuse and/or neglect and children with no history of CM. MethodsThis study included 65 children with a positive history of moderate to severe CM, as reported by themselves and their parent(s) during a clinical interview, and 71 children with no history of CM as a comparison group. CM was considered moderate to severe based on the child-reported frequency of being exposed to events related to sexual abuse, physical abuse, emotional abuse, emotional neglect, and/or physical neglect. Child psychopathology symptoms were assessed using the Child Behavior Checklist (CBCL). We measured serum copeptin concentration using enzyme-linked immunosorbent assay. ResultsChildren exposed to CM exhibited higher levels of serum copeptin compared to children without CM when controlling for sex, age, and psychiatric morbidity. The CBCL total score, including internalizing and externalizing symptoms, was higher in children with CM. We found no correlation between copeptin and CBCL scores for internalizing symptoms and externalizing symptoms. Conclusion CM is associated with copeptin serum levels independently of age, sex, and symptom severity. Copeptin is a promising new biomarker for children with a history of abuse and/or neglect. en
dc.description.sponsorship National Institute of Developmental Psychiatry for Children and Adolescents, a science and technology institute
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 434-441
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Psychiatry And Clinical Neurosciences
dc.rights Acesso aberto
dc.subject child abuse en
dc.subject child psychopathology en
dc.subject copeptin en
dc.subject hypothalamic-pituitary-adrenal axis en
dc.subject stress en
dc.title Serum copeptin in children exposed to maltreatment en
dc.type Artigo
dc.description.affiliation Pontifical Catholic Univ Rio Grande Sul PUCRS, DCNL, Ave Ipiranga 6681,Predio 11,Sala 928 Partenon, BR-90619900 Porto Alegre, RS, Brazil
dc.description.affiliation Univ Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS, Brazil
dc.description.affiliation CNPq, Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo, Brazil
dc.description.affiliation Fed Univ Sao Paulo UNIFESP, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci LINC, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Inst Psychiat IPq, Sao Paulo, Brazil
dc.description.affiliation Univ Toronto, Univ Hlth Network, MDPU, Toronto, ON, Canada
dc.description.affiliationUnifesp Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil
dc.description.affiliationUnifesp Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil
dc.description.sponsorshipID CNPq: 573974/2008-0
dc.description.sponsorshipID CNPq: 305141/2011-2
dc.description.sponsorshipID CNPq: 476468/ 2012-4
dc.description.sponsorshipID FAPESP: 2008/57896-8
dc.identifier.doi 10.1111/pcn.12412
dc.description.source Web of Science
dc.identifier.wos WOS:000385563800003
dc.coverage Hoboken
dc.citation.volume 70
dc.citation.issue 10



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