Serum copeptin in children exposed to maltreatment

Serum copeptin in children exposed to maltreatment

Author Coelho, Roberta Google Scholar
Levandowski, Mateus L. Google Scholar
Mansur, Rodrigo B. Google Scholar
Cunha, Graccielle Rodrigues da Autor UNIFESP Google Scholar
Asevedo, Elson Autor UNIFESP Google Scholar
Zugman, Andre Autor UNIFESP Google Scholar
Salum, Giovanni A. Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Pan, Pedro Mario Autor UNIFESP Google Scholar
Rizzo, Lucas Bortolotto Autor UNIFESP Google Scholar
Manfro, Gisele Google Scholar
Mari, Jair de Jesus Autor UNIFESP Google Scholar
Rohde, Luis A. Google Scholar
Miguel, Euripedes C. Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Grassi-Oliveira, Rodrigo Google Scholar
Abstract AimChildhood maltreatment (CM) has been related to a persistent reprograming of stress-response. Copeptin is a marker of hypothalamic-pituitary-adrenal axis activation

however, few studies have examined copeptin levels in children exposed to CM. The aim of this study was to compare serum copeptin levels in children reporting child abuse and/or neglect and children with no history of CM. MethodsThis study included 65 children with a positive history of moderate to severe CM, as reported by themselves and their parent(s) during a clinical interview, and 71 children with no history of CM as a comparison group. CM was considered moderate to severe based on the child-reported frequency of being exposed to events related to sexual abuse, physical abuse, emotional abuse, emotional neglect, and/or physical neglect. Child psychopathology symptoms were assessed using the Child Behavior Checklist (CBCL). We measured serum copeptin concentration using enzyme-linked immunosorbent assay. ResultsChildren exposed to CM exhibited higher levels of serum copeptin compared to children without CM when controlling for sex, age, and psychiatric morbidity. The CBCL total score, including internalizing and externalizing symptoms, was higher in children with CM. We found no correlation between copeptin and CBCL scores for internalizing symptoms and externalizing symptoms. Conclusion CM is associated with copeptin serum levels independently of age, sex, and symptom severity. Copeptin is a promising new biomarker for children with a history of abuse and/or neglect.
Keywords child abuse
child psychopathology
copeptin
hypothalamic-pituitary-adrenal axis
stress
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor National Institute of Developmental Psychiatry for Children and Adolescents, a science and technology institute
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number CNPq: 573974/2008-0
CNPq: 305141/2011-2
CNPq: 476468/ 2012-4
FAPESP: 2008/57896-8
Date 2016
Published in Psychiatry And Clinical Neurosciences. Hoboken, v. 70, n. 10, p. 434-441, 2016.
ISSN 1323-1316 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 434-441
Origin http://dx.doi.org/10.1111/pcn.12412
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000385563800003
URI https://repositorio.unifesp.br/handle/11600/56999

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