Peripheral immuno-inflammatory abnormalities in ultra-high risk of developing psychosis

Peripheral immuno-inflammatory abnormalities in ultra-high risk of developing psychosis

Author Zeni-Graiff, Maiara Autor UNIFESP Google Scholar
Rizzo, Lucas Bortolotto Autor UNIFESP Google Scholar
Mansur, Rodrigo Barbachan Autor UNIFESP Google Scholar
Maurya, Pawan Kumar Autor UNIFESP Google Scholar
Sethi, Sumit Autor UNIFESP Google Scholar
Cunha, Graccielle Rodrigues da Autor UNIFESP Google Scholar
Asevedo, Elson Autor UNIFESP Google Scholar
Pan, Pedro Mario Autor UNIFESP Google Scholar
Zugman, Andre Autor UNIFESP Google Scholar
Yamagata, Ana S. Autor UNIFESP Google Scholar
Higuchi, Cinthia Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Abstract Background: Immuno-inflammatory imbalances have been documented in schizophrenia, but very little is known about the immunological changes prior to the onset of disease. Objective: Thiswork aimed to compare serumlevels of pro-and anti-inflammatory cytokines in young subjects at ultra-high risk (UHR) of developing psychosis with age-and sex-matched healthy controls. Methods: A total of 12 UHR and 16 age-and sex-matched healthy controls (HC) subjects were enrolled in this study. Clinical profile was assessed using the Comprehensive Assessment of At-Risk Mental States (CAARMS), Semi-Structured Clinical Interview for DSM-IV Axis-I (SCID-I) or Kiddie-SADS-Present and Lifetime Version (KSADS-PL), and Global Assessment of Functioning (GAF) scale. Seruminterleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-alpha, IFN-gamma, and IL-17 were measured by flow cytometry using the Th1/Th2/Th17 cytometric bead array. Results: Compared with the healthy control group, patients in UHR showed increased IL-6 levels (Z=-2.370, p = 0.018) and decreased IL-17 levels in serum (Z = -1.959, p = 0.050). Levels of IL-17 positively correlated to the values in GAF symptoms (rho= 0.632, p = 0.028). Conclusion: Our results suggest that immunological imbalances could be present in the early stages of psychosis, including in at-risk stages. Future studies should replicate and expand these results. (C) 2016 Elsevier B.V. All rights reserved.
Keywords Ultra-high risk
Prodromal
Inflammation
Cytokines
Schizophrenia
Psychosis
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
L'oreal/UNESCO/Brazilian Academy of Sciences
Date 2016
Published in Schizophrenia Research. Amsterdam, v. 176, n. 43526, p. 191-195, 2016.
ISSN 0920-9964 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 191-195
Origin http://dx.doi.org/10.1016/j.schres.2016.06.031
Access rights Closed access
Type Article
Web of Science ID WOS:000384130200017
URI https://repositorio.unifesp.br/handle/11600/56989

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