Challenges and developments in research of the early stages of bipolar disorder

Challenges and developments in research of the early stages of bipolar disorder

Author Brietzke, Elisa Autor UNIFESP Google Scholar
Rosa, Adriane R. Google Scholar
Pedrini, Mariana Autor UNIFESP Google Scholar
Noto, Mariane Nunes Autor UNIFESP Google Scholar
Kapczinski, Flavio Google Scholar
Scott, Jan Google Scholar
Abstract Recently, attention in the field of bipolar disorder (BD) has focused on prevention, including early detection and intervention, as these strategies have the potential to delay, lessen the severity, or even prevent full-blown episodes of BD. Although knowledge of the neurobiology of BD has advanced substantially in the last two decades, most research was conducted with chronic patients. The objective of this paper is to comprehensively review the literature regarding the early stages of BD, to explore recent discoveries on the neurobiology of these stages, and to discuss implications for research and clinical care. The following databases were searched: PubMed, PsycINFO, Cochrane Library, and SciELO. Articles published in English from inception to December 2015 were retrieved. Several research approaches were used, including examination of offspring studies, retrospective studies, prospective studies of clinical high-risk populations, and exploration of the progression after the first manic episode. Investigations with neuroimaging, cognition assessments, and biomarkers provide promising (although not definitive) evidence of alterations in the neural substrate during the at-risk stage. Research on BD should be expanded to encompass at-risk states and aligned with recent methodological progress in neuroscience.
Keywords Bipolar disorder
early stages
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Science without Borders program
Medical Research Council
Research for Patient Benefit program
NTW FSF grant
Johnson Johnson
Grant number Research for Patient Benefit program: PB-PG-0609-16166
Date 2016
Published in Revista Brasileira De Psiquiatria. Sao Paulo, v. 38, n. 4, p. 329-337, 2016.
ISSN 1516-4446 (Sherpa/Romeo, impact factor)
Publisher Assoc Brasileira Psiquiatria
Extent 329-337
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000388469200012
SciELO ID S1516-44462016000400329 (statistics in SciELO)

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