Low-level laser therapy associated to a resistance training protocol on bone tissue in diabetic rats

Low-level laser therapy associated to a resistance training protocol on bone tissue in diabetic rats

Author Patrocinio-Silva, Tatiane Lopes Google Scholar
Fogaca de Souza, Andre Moreira Autor UNIFESP Google Scholar
Goulart, Raul Loppi Autor UNIFESP Google Scholar
Pegorari, Carolina Fuirini Autor UNIFESP Google Scholar
Oliveira, Jussan Rodrigues Autor UNIFESP Google Scholar
Fernandes, Kelly Rossetti Autor UNIFESP Google Scholar
Magri, Angela Maria Paiva Autor UNIFESP Google Scholar
Rodrigues Pereira, Rosa Maria Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Nagaoka, Marcia Regina Autor UNIFESP Google Scholar
Muniz Renno, Ana Claudia Autor UNIFESP Google Scholar
Abstract Objective: The present study aimed to evaluate the in vivo response of a resistance training and low-level laser therapy (LLLT) on tibias and femurs of rats with diabetes mellitus (DM). Materials and methods: Forty male Wistar rats were randomly distributed into four experimental groups: control group (CG), diabetic group (DG), diabetic trained group (TG) and diabetic trained and laser irradiated group (TLG). DM was induced by streptozotocin (STZ) and after two weeks laser and resistance training started, performed for 24 sessions, during eight weeks. At the end of the experiment, animals were euthanized and tibias and femurs were removed for analysis. Histological, histomorphometrical, immunohistochemistry and mechanical analyses were performed. Results: Trained groups, with or without laser irradiation, showed increased cortical area, bone density and biomechanical properties. The immunohistochemical analysis revealed that TG and TLG demonstrated an increased RUNX2 expression. RANK-L immunoexpression was similar for all experimental groups. Conclusion: In conclusion, it can be suggested that the resistance exercise program stimulated bone metabolism, culminating in increased cortical tibial area, bone mineral content, bone mineral density and biomechanical properties. Furthermore, the association of physical exercises and LLLT produced higher values for bone mineral content and stiffness. Consequently, these data highlight the potential of physical exercise in the management of bone loss due to DM and the possible extra osteogenic stimulus offered by lasertherapy. Further long-term studies should be carried out to provide additional information.
Keywords Low-level laser therapy
resistance training
diabetes mellitus
bone
xmlui.dri2xhtml.METS-1.0.item-coverage Rio De Janeiro, Rj
Language English
Date 2016
Published in Archives Of Endocrinology Metabolism. Rio De Janeiro, Rj, v. 60, n. 5, p. 457-464, 2016.
ISSN 2359-3997 (Sherpa/Romeo, impact factor)
Publisher Sbem-Soc Brasil Endocrinologia & Metabologia
Extent 457-464
Origin http://dx.doi.org/10.1590/2359-3997000000190
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000388955900008
SciELO ID S2359-39972016000500457 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/56957

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