Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndrome

Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndrome

Autor Peres, Paulo Alberto Autor UNIFESP Google Scholar
Bernardelli, Graziella França Autor UNIFESP Google Scholar
Mendes, Cássia Claudino Autor UNIFESP Google Scholar
Fischer, Sven C P M Autor UNIFESP Google Scholar
Servantes, Denise Maria Autor UNIFESP Google Scholar
Medeiros, Wladimir Musetti Autor UNIFESP Google Scholar
Carvalho, Antonio Carlos Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Marfan syndrome (MS) is a dominant autosomal disease caused by mutations in chromosome 15, the locus controlling fibrillin 1 synthesis, and may exhibit skeletal, ocular, cardiovascular, and other manifestations. Pulse wave velocity (PWV) is used to measure arterial elasticity and stiffness and is related to the elastic properties of the vascular wall. Since the practice of exercise is limited in MS patients, it was of interest to analyze the acute effect of submaximal exercise on aortic distensibility using PWV and other hemodynamic variables in patients with MS with either mild or no aortic dilatation. PWV and physiological variables were evaluated before and after submaximal exercise in 33 patients with MS and 18 controls. PWV was 8.51 ± 0.58 at rest and 9.10 ± 0.63 m/s at the end of exercise (P = 0.002) in the group with MS and 8.07 ± 0.35 and 8.98 ± 0.56 m/s in the control group, respectively (P = 0.004). Comparative group analysis regarding PWV at rest and at the end of exercise revealed no statistically significant differences. The same was true for the group that used β-blockers and the one that did not. The final heart rate was 10% higher in the control group than in the MS group (P = 0.01). Final systolic arterial pressure was higher in the control group (P = 0.02). PWV in MS patients with mild or no aortic dilatation did not differ from the control group after submaximal effort.
Palavra-chave Exercise
Aortic elasticity
Pulse wave velocity
Marfan syndrome
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Data de publicação 2010-04-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 43, n. 4, p. 397-402, 2010.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 397-402
Fonte http://dx.doi.org/10.1590/S0100-879X2010007500021
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000276670300011
SciELO S0100-879X2010000400011 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/5691

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