Validity of the Portuguese CHO-KLAT in Brazil

Validity of the Portuguese CHO-KLAT in Brazil

Author Villaca, Paula Ribeiro Google Scholar
Blanchette, V. S. Google Scholar
Carneiro, J. D. A. Google Scholar
Ozelo, Margareth Castro Google Scholar
Antunes, Sandra Vallin Autor UNIFESP Google Scholar
Feldman, B. M. Google Scholar
Abad, A. Google Scholar
Usuba, K. Google Scholar
Young, N. L. Google Scholar
Abstract IntroductionIt is essential to assess the health-related quality of life outcomes of boys with haemophilia in Brazil. The Canadian Haemophilia Outcomes-Kids Life Assessment Tool (CHO-KLAT) was recently adapted for this population. AimTo test the construct validity of the Portuguese version of the CHO-KLAT. MethodsWe recruited 50 boys, with moderate [factor VIII (FVIII) level 1-5%] or severe (FVIII level <1%) haemophilia, to participate in a descriptive study to establish a baseline understanding of the current status of boys with haemophilia in Brazil. All boys were required to complete the Brazilian CHO-KLAT and Brazilian Pediatric Quality of Life Inventory (PedsQL) by self-report. We examined the correlation between the CHO-KLAT and PedsQL scores to establish the construct validity of the Brazilian version of the CHO-KLAT. ResultsWe obtained CHO-KLAT and PedsQL data from 35 boys with severe haemophilia and 15 with moderate haemophilia. They ranged in age from 7.3 to 18.0 years, with a mean of 13.0 years. They reported a mean CHO-KLAT score of 72.3 (range = 44.1-93.9). The mean PedsQL score was 79.9 (range = 45.7-96.7), with physical health (mean of 83.9) being better than psychosocial health (77.8). The Pearson's correlation between CHO-KLAT and PedsQL was 0.47 respectively (P < 0.001). The CHO-KLAT had a moderate and inverse relationship with the degree to which they were bothered by their haemophilia ( = -0.53), while the PedsQL had a weaker relationship ( = -0.27). ConclusionThe results confirm the validity of the Portuguese version of the CHO-KLAT. This measure is now available for clinical trials in boys with haemophilia in Brazil.
Keywords haemophilia
outcome measurement
quality of life
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor Baxalta US Inc. Corporation through Baxalta Grants competition
Date 2016
Published in Haemophilia. Hoboken, v. 22, n. 6, p. 894-897, 2016.
ISSN 1351-8216 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 894-897
Access rights Closed access
Type Article
Web of Science ID WOS:000388493000027

Show full item record


File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)




My Account