Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres

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dc.contributor.author Reno, Caroline de Oliveira [UNIFESP]
dc.contributor.author Motisuke, Mariana [UNIFESP]
dc.date.accessioned 2020-07-31T12:47:20Z
dc.date.available 2020-07-31T12:47:20Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1590/1980-5373-MR-2016-0189
dc.identifier.citation Materials Research-Ibero-American Journal Of Materials. Sao Carlos, v. 19, n. 6, p. 1388-1392, 2016.
dc.identifier.issn 1516-1439
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/56763
dc.description.abstract Spherical calcium phosphate cement carriers were synthesized by water/oil emulsion. A 23 factorial design was employed in order to optimize the size and form of the microspheres. Stirring speed, liquid-to-powder ratio and cement paste-to-oil ratio were varied in two different levels and the response variable was the microsphere's sphericity. The results showed that cement's setting reaction was responsible for stabilizing the microspheres within the oil phase resulting in a low crystalline hydroxyapatite. The sizes varied from 6.29 to 64.23 mu m. From the factors studied, the stirring velocity and the interaction between the L/P ratio with the P/O ratio are the ones that are more effective in controlling microspheres' sphericity. The results suggest that the methodology studied may provide microspheres with appropriate properties to deliver cells and/or drugs without inducing inflammatory reactions. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 1388-1392
dc.language.iso eng
dc.publisher Univ Fed Sao Carlos, Dept Engenharia Materials
dc.relation.ispartof Materials Research-Ibero-American Journal Of Materials
dc.rights Acesso aberto
dc.subject calcium phosphate cement en
dc.subject microspheres en
dc.subject water/oil emulsion en
dc.subject alpha- tricalcium phosphate en
dc.subject factorial design en
dc.title Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres en
dc.type Artigo
dc.description.affiliation UNIFESP, Inst Sci & Technol, Bioceram Lab, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnifesp Bioceramics Laboratory, Science and Technology Institute - Universidade Federal de São Paulo (UNIFESP), São José dos Campos, SP, Brazil
dc.description.sponsorshipID FAPESP: 2012/21198-0
dc.description.sponsorshipID FAPESP: 2013/26248-9
dc.description.sponsorshipID FAPESP: 2011/09240-9
dc.description.sponsorshipID FAPESP: 2013/19642-2
dc.identifier.file S1516-14392016000601388.pdf
dc.identifier.scielo S1516-14392016000601388
dc.identifier.doi 10.1590/1980-5373-MR-2016-0189
dc.description.source Web of Science
dc.identifier.wos WOS:000391716900009
dc.coverage Sao Carlos
dc.citation.volume 19
dc.citation.issue 6


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