Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres

Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres

Author Reno, Caroline de Oliveira Autor UNIFESP Google Scholar
Motisuke, Mariana Autor UNIFESP Google Scholar
Abstract Spherical calcium phosphate cement carriers were synthesized by water/oil emulsion. A 23 factorial design was employed in order to optimize the size and form of the microspheres. Stirring speed, liquid-to-powder ratio and cement paste-to-oil ratio were varied in two different levels and the response variable was the microsphere's sphericity. The results showed that cement's setting reaction was responsible for stabilizing the microspheres within the oil phase resulting in a low crystalline hydroxyapatite. The sizes varied from 6.29 to 64.23 mu m. From the factors studied, the stirring velocity and the interaction between the L/P ratio with the P/O ratio are the ones that are more effective in controlling microspheres' sphericity. The results suggest that the methodology studied may provide microspheres with appropriate properties to deliver cells and/or drugs without inducing inflammatory reactions.
Keywords calcium phosphate cement
microspheres
water/oil emulsion
alpha- tricalcium phosphate
factorial design
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Carlos
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2012/21198-0
FAPESP: 2013/26248-9
FAPESP: 2011/09240-9
FAPESP: 2013/19642-2
Date 2016
Published in Materials Research-Ibero-American Journal Of Materials. Sao Carlos, v. 19, n. 6, p. 1388-1392, 2016.
ISSN 1516-1439 (Sherpa/Romeo, impact factor)
Publisher Univ Fed Sao Carlos, Dept Engenharia Materials
Extent 1388-1392
Origin http://dx.doi.org/10.1590/1980-5373-MR-2016-0189
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000391716900009
SciELO ID S1516-14392016000601388 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/56763

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