Crack cocaine addiction, early life stress and accelerated cellular aging among women

Crack cocaine addiction, early life stress and accelerated cellular aging among women

Author Levandowski, Mateus Luz Google Scholar
Tractenberg, Saulo Gantes Google Scholar
de Azeredo, Lucas Araujo Google Scholar
De Nardi, Tatiana Google Scholar
Rovaris, Diego L. Google Scholar
Bau, Claiton H. D. Google Scholar
Rizzo, Lucas Bortolotto Autor UNIFESP Google Scholar
Maurya, Pawan Kumar Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Tyrka, Audrey R. Google Scholar
Grassi-Oliveira, Rodrigo Google Scholar
Abstract Background: Early life stress (ELS) and addiction are related to age-related diseases and telomere shortening. However, the role of telomere length (TL) in crack cocaine addiction remains unknown. The purpose of this study was to investigate the TL in a sample of crack cocaine dependent-women who reported an ELS history and in a community-based sample of elderly women as a reference group for senescence. Methods: This study included treatment seeking crack cocaine dependents women (n = 127) and elderly women without a psychiatric diagnosis (ELD, n = 49). The crack cocaine sample was divided in two groups according to their Childhood Trauma Questionnaire (CTQ) scores: presence of history of childhood abuse and neglect (CRACK-ELS) and absence of ELS history (CRACK). TL was assessed by T/S ratio obtained from peripheral blood DNA using quantitative PCR assay. esults: CRACK and CRACK-ELS subjects exhibited shortened TL in comparison to the ELD group, despite their younger age. Among crack cocaine sample, CRACK-ELS group had significantly shorter telomeres than the CRACK group. Correlation analysis within crack cocaine group indicated that TL was negatively correlated with emotional abuse scores. Conclusions: These results support previous findings associating telomere shortening with both ELS and drug addiction. This study suggests new evidence of a distinct biological phenotype for drug-dependent women with ELS. The results support the biological senescence hypothesis underpinning ELS experience. (C) 2016 Elsevier Inc. All rights reserved.
Keywords Aging
Child abuse
Cocaine
Senescence
Substance-related disorders
Telomere
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Date 2016
Published in Progress In Neuro-Psychopharmacology & Biological Psychiatry. Oxford, v. 71, p. 83-89, 2016.
ISSN 0278-5846 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 83-89
Origin http://dx.doi.org/10.1016/j.pnpbp.2016.06.009
Access rights Closed access
Type Article
Web of Science ID WOS:000382204200010
URI https://repositorio.unifesp.br/handle/11600/56725

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