Physiological and sensory consequences of exercise oscillatory ventilation in heart failure-COPD

Physiological and sensory consequences of exercise oscillatory ventilation in heart failure-COPD

Author Rocha, Alcides Autor UNIFESP Google Scholar
Arbex, Flavio Ferlin Autor UNIFESP Google Scholar
Alencar, Maria Clara Noman de Autor UNIFESP Google Scholar
Sperandio, Priscila Abreu Autor UNIFESP Google Scholar
Hirai, Daniel Müller Autor UNIFESP Google Scholar
Berton, Danilo C. Google Scholar
O'Donnell, Denis E. Google Scholar
Neder, Jose Alberto Autor UNIFESP Google Scholar
Abstract Background: Exercise oscillatory ventilation (EOV) is associatedwith poor ventilatory efficiency and higher operating lung volumes in heart failure. These abnormalitiesmay be particularly deleterious to dyspnea and exercise tolerance in mechanically-limited patients, e.g. those with coexistent COPD. Methods: Ventilatory, gas exchange and sensory responses to incremental exercise were contrasted in 68 heart failure-COPD patients (12 EOV+). EOV was established by standard criteria. Results: Compared to EOV-, EOV+ had lower exercise capacity, worse ventilatory inefficiency and higher peak dyspnea scores (p < 0.05). Peak capillary PCO2 (PcCO2) was higher and end-tidal CO2 (PETCO2) was lower in EOV+. Thus, greater (i.e., more positive) P(c-ET) CO2 and dead space/tidal volume values were found in these patients compared to EOV- (p < 0.05). Ventilatory inefficiency was related to increased dead space/tidal volumein EOV+ (r = 0.74

p < 0.01). Owing to higher operating lung volumes, inspiratory reserve volume (IRV) decreased to a greater extent in EOV+. Tidal volume oscillations consistently ceased when a "critical" IRV was reached (similar to 0.3-0.5 L)

thereafter, PcCO2 stabilized or increased and dyspnea scores rose sharply. Exercise capacity was closely related to IRV decrements and peak dyspnea in EOV+ (r = -0.78 and 0.84, respectively

p < 0.01). Conclusions: Dyspnea and exercise tolerance are negatively influenced by EOV in heart failure patients presenting with COPD as co-morbidity. Pharmacological and non-pharmacological interventions known to decrease EOV might prove particularly valuable to mitigate symptomburden and exercise intolerance in this specific heart failure group. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Keywords Heart failure
COPD
Exertion
Ventilation
Lung mechanics
Dyspnea
xmlui.dri2xhtml.METS-1.0.item-coverage Clare
Language English
Date 2016
Published in International Journal Of Cardiology. Clare, v. 224, p. 447-453, 2016.
ISSN 0167-5273 (Sherpa/Romeo, impact factor)
Publisher Elsevier Ireland Ltd
Extent 447-453
Origin http://dx.doi.org/10.1016/j.ijcard.2016.09.077
Access rights Closed access
Type Article
Web of Science ID WOS:000390471300081
URI https://repositorio.unifesp.br/handle/11600/56623

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