beta-Carotene-loaded nanostructured lipid carriers produced by solvent displacement method

beta-Carotene-loaded nanostructured lipid carriers produced by solvent displacement method

Author Bernardes Oliveira, Davi Rocha Google Scholar
Michelon, Mariano Google Scholar
Furtado, Guilherme de Figueiredo Google Scholar
Sinigaglia-Coimbra, Rita Autor UNIFESP Google Scholar
Cunha, Rosiane Lopes Google Scholar
Abstract Tristearin solid lipid nanoparticles and tristearin/high oleic sunflower oil nanostructured lipid carriers were produced by solvent displacement method. All conditions allowed forming polydisperse particles within nanometric range and the presence of high oleic sunflower oil did not affect the particles mean size. Nevertheless, incorporation of beta-carotene reduced the particles polydispersity. Thermograms of solid lipid nanoparticles and nano structured lipid carriers showed that sunflower oil generated a crystal order disturbance, since nanoparticles with less-organized lipid matrix were produced. Nanostructured lipid carriers exhibited an improvement of beta-carotene loading capacity when compared with solid lipid nanoparticles, which enhanced with the increasing of high oleic sunflower oil content. Although total beta-carotene degradation was similar for all systems, color analysis showed that the degradation of encapsulated beta-carotene was lower for high sunflower oil content. Nano structured lipid carriers exhibited advantages over the solid lipid nanoparticles, such as enhanced drug loading capacity and prevention of drug expulsion, which makes this a versatile delivery system for food applications. (C) 2016 Elsevier Ltd. All rights reserved.
Keywords Solid lipid nanoparticle
Nanostructured lipid carrier
beta-carotene
High oleic sunflower oil
Solvent displacement
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)(DEA/FEA/PROEX)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: EMU2009/54137-1
FAPESP: 2007/54520-4
FAPESP: 2006/03263-9
CNPq: 305477/2012-9
Date 2016
Published in Food Research International. Amsterdam, v. 90, p. 139-146, 2016.
ISSN 0963-9969 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 139-146
Origin http://dx.doi.org/10.1016/j.foodres.2016.10.038
Access rights Closed access
Type Article
Web of Science ID WOS:000390636700016
URI https://repositorio.unifesp.br/handle/11600/56621

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