A Current Snapshot of Common Genomic Variants Contribution in Psychiatric Disorders

A Current Snapshot of Common Genomic Variants Contribution in Psychiatric Disorders

Author Santoro, Marcos Leite Autor UNIFESP Google Scholar
Moretti, Patricia N. Autor UNIFESP Google Scholar
Pellegrino, Renata Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Abilio, Vanessa Costhek Autor UNIFESP Google Scholar
Hayashi, Mirian Akemi Furuie Autor UNIFESP Google Scholar
Belangero, Sintia Iole Autor UNIFESP Google Scholar
Hakonarson, Hakon Google Scholar
Abstract In the past decade, numerous advances were achieved in psychiatric genetics. Particularly, the genome wide association studies (GWAS) have contributed to uncovering new genes and pathways associated to psychiatric disorders (PDs). At the same time, with increasing sample sizes in the GWAS, the polygenic risk score (PRS) promoted an additional tool for identification and evaluation the genetic risk quantitatively in PDs. This concept review presents the state of the art GWAS analysis and PRS focusing on the genetic underpinnings of PDs. (C) 2016 Wiley Periodicals, Inc.
Keywords GWAS
psychiatry
polygenic risk score
psychiatric disorder
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Y-Mind Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number Y-Mind FAPESP: 12/50316-1
Date 2016
Published in American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics. Hoboken, v. 171, n. 8, p. 997-1005, 2016.
ISSN 1552-4841 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent 997-1005
Origin http://dx.doi.org/10.1002/ajmg.b.32475
Access rights Closed access
Type Article
Web of Science ID WOS:000390663500024
URI https://repositorio.unifesp.br/handle/11600/56618

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