Selfish brain and selfish immune system interplay: A theoretical framework for metabolic comorbidities of mood disorders

Selfish brain and selfish immune system interplay: A theoretical framework for metabolic comorbidities of mood disorders

Author Yamagata, Ana Sayuri Autor UNIFESP Google Scholar
Mansur, Rodrigo Barbachan Autor UNIFESP Google Scholar
Rizzo, Lucas Bortolotto Autor UNIFESP Google Scholar
Rosenstock, Tatiana Google Scholar
McIntyre, Roger S. Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Abstract According to the "selfish brain" theory, the brain regulates its own energy supply influencing the peripheral metabolism and food intake according to its needs. The immune system has been likewise "selfish" due to independent energy consumption

and it may compete with the brain (another high energy consumer) for glucose. In mood disorders, stress in mood episodes or physiological stress activate homeostasis mechanisms from the brain and the immune system to solve the imbalance. The interaction between the selfish brain and the selfish immune system may explain various conditions of medical impairment in mood disorders, such as Metabolic Syndrome (MetS), obesity, type 2 diabetes mellitus (T2DM) and immune dysregulation. The objective of this study is to comprehensively review the literature regarding the competition between the brain and the immune system for energy substrate. Targeting the energetic regulation of the brain and the immune system and their cross-talk open alternative treatments and a different approach in the study of general medical comorbidities in mood disorders, although more investigation is needed. (C) 2016 Elsevier Ltd. All rights reserved.
Keywords Bipolar disorder
Major depressive disorder
Brain energy metabolism
Immune system energy metabolism
Metabolic syndrome
Inflammation
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Date 2017
Published in Neuroscience And Biobehavioral Reviews. Oxford, v. 72, p. 43-49, 2017.
ISSN 0149-7634 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 43-49
Origin http://dx.doi.org/10.1016/j.neubiorev.2016.11.010
Access rights Closed access
Type Article
Web of Science ID WOS:000392789900004
URI https://repositorio.unifesp.br/handle/11600/56473

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