Biomarkers of spontaneous preterm birth: a systematic review of studies using multiplex analysis

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dc.contributor.author Polettini, Jossimara
dc.contributor.author Cobo, Teresa
dc.contributor.author Kacerovsky, Marian
dc.contributor.author Vinturache, Angela E.
dc.contributor.author Laudanski, Piotr
dc.contributor.author Peelen, Myrthe J. C. S.
dc.contributor.author Helmer, Hanns
dc.contributor.author Lamont, Ronald F.
dc.contributor.author Takeda, Jun
dc.contributor.author Lapointe, Jerome
dc.contributor.author Torloni, Maria Regina [UNIFESP]
dc.contributor.author Zhong, Nanbert
dc.contributor.author Menon, Ramkumar
dc.date.accessioned 2020-07-31T12:46:56Z
dc.date.available 2020-07-31T12:46:56Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1515/jpm-2016-0097
dc.identifier.citation Journal Of Perinatal Medicine. Berlin, v. 45, n. 1, p. 71-84, 2017.
dc.identifier.issn 0300-5577
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/56466
dc.description.abstract Objective: Despite decades of research on risk indicators of spontaneous preterm birth (PTB), reliable biomarkers are still not available to screen or diagnose high-risk pregnancies. Several biomarkers in maternal and fetal compartments have been mechanistically linked to PTB, but none of them are reliable predictors of pregnancy outcome. This systematic review was conducted to synthesize the knowledge on PTB biomarkers identified using multiplex analysis. Materials and methods: Three electronic databases (PubMed, EMBASE and Web of Science) were searched for studies in any language reporting the use of multiplex assays for maternal biomarkers associated with PTB published from January 2005 to March 2014. Results: Retrieved citations (3631) were screened, and relevant studies (33) were selected for full-text reading. Ten studies were included in the review. Forty-two PTB-related proteins were reported, and RANTES and IL-10 (three studies) followed by MIP-1 beta, GM-CSF, Eotaxin, and TNF-RI (two studies) were reported more than once in maternal serum. However, results could not be combined due to heterogeneity in type of sample, study population, assay, and analysis methods. Conclusion: By this systematic review, we conclude that multiplex assays are a potential technological advancement for identifying biomarkers of PTB, although no single or combination of biomarkers could be identified to predict PTB risk. en
dc.description.sponsorship Hologic, Inc., CA, USA
dc.description.sponsorship PREBIC Annual Meeting in Florence, Italy
dc.format.extent 71-84
dc.language.iso eng
dc.publisher Walter De Gruyter Gmbh
dc.relation.ispartof Journal Of Perinatal Medicine
dc.rights Acesso restrito
dc.subject Biological markers en
dc.subject cytokines en
dc.subject multiplex assay en
dc.subject prematurity en
dc.title Biomarkers of spontaneous preterm birth: a systematic review of studies using multiplex analysis en
dc.type Artigo
dc.description.affiliation Univ Texas Med Branch, Dept Obstet & Gynecol, Div Maternal Fetal Med & Perinatal Res, MRB, 301 Univ Blvd,Room 11-138, Galveston, TX 77555 USA
dc.description.affiliation Univ Western Sao Paulo, UNOESTE, Fac Hlth Sci, Sao Paulo, Brazil
dc.description.affiliation Univ Barcelona, Inst Biomed Invest August Pi i Sunyer IDIBAPS, Maternal Fetal Med Dept, Hosp Clin, Barcelona, Spain
dc.description.affiliation Univ Hosp Hradec Kralove, Biomed Res Ctr, Hradec Kralove, Czech Republic
dc.description.affiliation Charles Univ Prague, Dept Obstet & Gynecol, Fac Med Hradec Kralove, Univ Hosp Hradec Kralove, CR-11636 Prague 1, Czech Republic
dc.description.affiliation Univ Calgary, Cumming Sch Med, Dept Pediat, Calgary, AB, Canada
dc.description.affiliation Med Univ Bialystok, Dept Perinatol & Obstet, Bialystok, Poland
dc.description.affiliation Acad Med Ctr, Dept Obstet & Gynecol, Amsterdam, Netherlands
dc.description.affiliation Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria
dc.description.affiliation UCL, Div Surg, Northwick Pk Inst Med Res Campus, London, England
dc.description.affiliation Univ Southern Denmark, Odense Univ Hosp, Dept Gynecol & Obstet, Inst Clin Res,Res Unit Gynecol & Obstet, Odense, Denmark
dc.description.affiliation Juntendo Univ, Fac Med, Dept Obstet & Gynecol, Tokyo, Japan
dc.description.affiliation Hologic, Sunnyvale, CA USA
dc.description.affiliation Univ Fed Sao Paulo, UNIFESP, Dept Obstet, Sao Paulo, SP, Brazil
dc.description.affiliation New York State Inst Basic Res Dev Disabil, 1050 Forest Hill Rd, Staten Isl, NY 10314 USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo (UNIFESP), Dept Obstet, Sao Paulo, SP, Brazil
dc.identifier.doi 10.1515/jpm-2016-0097
dc.description.source Web of Science
dc.identifier.wos WOS:000393201100010
dc.coverage Berlin
dc.citation.volume 45
dc.citation.issue 1



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