Highly sensitive C-reactive protein and male gender are independently related to the severity of coronary disease in patients with metabolic syndrome and an acute coronary event

Highly sensitive C-reactive protein and male gender are independently related to the severity of coronary disease in patients with metabolic syndrome and an acute coronary event

Autor Monteiro, Carlos Manoel de Castro Autor UNIFESP Google Scholar
Pinheiro, Luiz Fernando Muniz Autor UNIFESP Google Scholar
Izar, Maria Cristina de Oliveira Autor UNIFESP Google Scholar
Barros, Sahana W. Autor UNIFESP Google Scholar
Vasco, M.Brandão Autor UNIFESP Google Scholar
Fischer, Simone M. Autor UNIFESP Google Scholar
Póvoa, Rui Manuel dos Santos Autor UNIFESP Google Scholar
Brandão, Sergio Augusto Bueno Autor UNIFESP Google Scholar
Santos, Andreza Oliveira dos Autor UNIFESP Google Scholar
Oliveira, Luciene Autor UNIFESP Google Scholar
Carvalho, Antonio Carlos Autor UNIFESP Google Scholar
Fonseca, Francisco Antonio Helfenstein Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Patients with metabolic syndrome are at high-risk for development of atherosclerosis and cardiovascular events. The objective of this study was to examine the major determinants of coronary disease severity, including those coronary risk factors associated with metabolic syndrome, during the early period after an acute coronary episode. We tested the hypothesis that inflammatory markers, especially highly sensitive C-reactive protein (hsCRP), are related to coronary atherosclerosis, in addition to traditional coronary risk factors. Subjects of both genders aged 30 to 75 years (N = 116) were prospectively included if they had suffered a recent acute coronary syndrome (acute myocardial infarction or unstable angina pectoris requiring hospitalization) and if they had metabolic syndrome diagnosed according to the National Cholesterol Education Program/Adult Treatment Panel III. Patients were submitted to a coronary angiography and the burden of atherosclerosis was estimated by the Gensini score. The severity of coronary disease was correlated (Spearman’s or Pearson’s coefficient) with gender (r = 0.291, P = 0.008), age (r = 0.218, P = 0.048), hsCRP (r = 0.256, P = 0.020), ApoB/ApoA ratio (r = 0.233, P = 0.041), and carotid intima-media thickness (r = 0.236, P = 0.041). After multiple linear regression, only male gender (P = 0.046) and hsCRP (P = 0.012) remained independently associated with the Gensini score. In this high-risk population, male gender and high levels of hsCRP, two variables that can be easily obtained, were associated with more extensive coronary disease, identifying patients with the highest potential of developing new coronary events.
Palavra-chave Metabolic syndrome
Acute coronary syndrome
C-reactive protein
Gensini score
Idioma Inglês
Data de publicação 2010-03-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 43, n. 3, p. 297-302, 2010.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 297-302
Fonte http://dx.doi.org/10.1590/S0100-879X2010005000008
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000275596000012
SciELO S0100-879X2010000300012 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/5646

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