Immune activation in amniotic fluid from Zika virus-associated microcephaly

Immune activation in amniotic fluid from Zika virus-associated microcephaly

Author Ornelas, Alice M. M. Google Scholar
Pezzuto, Paula Google Scholar
Silveira, Paola P. Google Scholar
Melo, Fabiana O. Google Scholar
Ferreira, Thales A. Google Scholar
Szejnfeld, Patricia Oliveira Autor UNIFESP Google Scholar
Leal, Jeime I. Google Scholar
Amorim, Melania M. R. Google Scholar
Hamilton, Stuart Google Scholar
Rawlinson, William D. Google Scholar
Cardoso, Cynthia C. Google Scholar
Nixon, Douglas F. Google Scholar
Tanuri, Amilcar Google Scholar
Melo, Adriana S. Google Scholar
Aguiar, Renato S. Google Scholar
Abstract Recent advances in the understanding of neuropathogenesis associated with Zika virus (ZIKV) infection has led to descriptions of neonatal microcephaly cases. However, none of these reports have evaluated the humoral response during ZIKV infection. We report here polyfunctional immune activation associated with increased interferon-gamma-inducible protein 10, interleukin (IL)-6, IL-8, vascular endothelial growth factor (VEGF), monocyte chemoattractive protein 1 (MCP-1), and granulocyte colony-stimulating factor (G-CSF) levels in the amniotic fluid of ZIKV-positive pregnant women with neonatal microcephaly. These cytokines have been associated not only with neuronal damage, but also with differentiation and proliferation of neural progenitor cells. Our results suggested that the immune activation caused by ZIKV infection in the uterine environment could also interfere with fetal development. ANN NEUROL 2017;81:152-156
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2017
Published in Annals Of Neurology. Hoboken, v. 81, n. 1, p. 152-156, 2017.
ISSN 0364-5134 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 152-156
Access rights Closed access
Type Article
Web of Science ID WOS:000393562300015

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