Benzodiazepines for restless legs syndrome

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dc.contributor.author Carlos, Karla [UNIFESP]
dc.contributor.author Prado, Gilmar Fernandes do [UNIFESP]
dc.contributor.author Teixeira, Camila de Masi [UNIFESP]
dc.contributor.author Conti, Cristiane
dc.contributor.author de Oliveira, Marcio M.
dc.contributor.author Prado, Lucila Bizari Fernandes do [UNIFESP]
dc.contributor.author Carvalho, Luciane Bizari Coin de [UNIFESP]
dc.date.accessioned 2020-07-31T12:46:36Z
dc.date.available 2020-07-31T12:46:36Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1002/14651858.CD006939.pub2
dc.identifier.citation Cochrane Database Of Systematic Reviews. Hoboken, v. , n. 3, p. -, 2017.
dc.identifier.issn 1469-493X
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/56297
dc.description.abstract Background Restless legs syndrome (RLS) is a common disease affecting about 5% to 15% of the population. Symptoms of RLS can be severe in a minority of and can have a major impact on sleep, mostly sleep initiation, and quality of life. Benzodiazepines are drugs that can induce and maintain sleep and, hence, intuitively are thought to be beneficial to people with RLS. Altough benzodiazepines, particularly clonazepam, are used to treat RLS symptoms, a systematic review done by the American Academy of SleepMedicine stated that benzodiazepines should not be used as a first-line treatment, although could be used as a coadjuvant therapy. Objectives To evaluate the efficacy and safety of benzodiazepine compared to placebo or other treatment for idiopathic RLS, including uncon-founded trials comparing benzodiazepines versus open control. Search methods In March 2016 we searched CENTRAL, MEDLINE, Embase and LILACS We checked the references of each study and contacted study authors to identify any additional studies. We considered studies published in any language. Selection criteria Randomised clinical trials of benzodiazepine treatment in idiopathic RLS. Data collection and analysis We did not perform data collection and analysis, since we did not include any studies, Main results We did not identify any studies that met the inclusion criteria of the review. Two cross-over studies are awaiting classification because the cross-over trials did not give data at the end of the first cross-over period. Authors' conclusions The effectiveness of benzodiazepines for RLS treatment is currently unknown. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent -
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Cochrane Database Of Systematic Reviews
dc.rights Acesso aberto
dc.title Benzodiazepines for restless legs syndrome en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Escola Paulista Med, Dept Neurol, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Maranhao, Dept Morphol, Sao Luis, Brazil
dc.description.affiliationUnifesp Department of Neurology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.sponsorshipID CNPq: 300646/2013-5
dc.identifier.doi 10.1002/14651858.CD006939.pub2
dc.description.source Web of Science
dc.identifier.wos WOS:000400761200021
dc.coverage Hoboken
dc.citation.issue 3



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