REM sleep deprivation impairs muscle regeneration in rats

REM sleep deprivation impairs muscle regeneration in rats

Author Mônico-Neto, Marcos Autor UNIFESP Google Scholar
Dattilo, Murilo Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Lee, Kil Sun Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Antunes, Hanna Karen Moreira Autor UNIFESP Google Scholar
Abstract Introduction: The aim was observe the influence of sleep deprivation (SD) and sleep recovery on muscle regeneration process in rats submitted to cryolesion. Methods: Thirty-two Wistar rats were randomly allocated in four groups: control (CTL), SD for 96 h (SD96), control plus sleep recovery period (CTL + R) and SD96h plus 96 h of sleep recovery (SD96 + R). The animals were submitted to muscle injury by cryolesioning, after to SD and sleep recovery. Results: The major outcomes of this study were the reduction of muscular IGF-1 in both legs (injured and uninjured) and a delay in muscle regeneration process of animals submitted to SD compared to animals that slept, with increase connective tissue, inflammatory infiltrate and minor muscle fibers. Conclusions: SD impairs muscle regeneration in rats, moreover reduces muscular IGF-1 and sleep recovery was able to restore it to basal levels, but it was not enough to normalize the muscle regeneration.
Keywords IGF-1
sleep loss
skeletal muscle
muscle recovery
xmlui.dri2xhtml.METS-1.0.item-coverage Abingdon
Language English
Sponsor Centros de Pesquisa, Inovação e Difusão (CEPID)/SONO/FAPESP
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 2009/11056-1
FAPESP: 2011/15962-7
FAPESP: 2013/00152-5
CEPID/SONO-FAPESP: 98/14303-3
Date 2017
Published in Growth Factors. Abingdon, v. 35, n. 1, p. 12-18, 2017.
ISSN 0897-7194 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 12-18
Origin http://dx.doi.org/10.1080/08977194.2017.1314277
Access rights Closed access
Type Article
Web of Science ID WOS:000403938000002
URI https://repositorio.unifesp.br/handle/11600/56271

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